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Titolo:
Hippocampal volume in first-episode psychoses and chronic schizophrenia - A high-resolution magnetic resonance imaging study
Autore:
Velakoulis, D; Pantelis, C; McGorry, PD; Dudgeon, P; Brewer, W; Cook, M; Desmond, P; Bridle, N; Tierney, P; Murrie, V; Singh, B; Copolov, D;
Indirizzi:
MentalParkville,Inst, Natl Hlth & Med Res Council, Schizophrenia Res Unit,Mental Hlth Res Inst Parkville Vic Australia 3052 Schizophrenia Res Unit, MentalaHlth Res Inst, Appl Schizophrenia Div, Parkville, Vic 3052, Australi Mental Hlth Res Inst Parkville Vic Australia 3052 lle, Vic 3052, Australi Royal Melbourne Hosp, Melbourne, Vic, Australia Royal Melbourne Hosp Melbourne Vic Australia , Melbourne, Vic, Australia Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia St Vincents Hosp, Melbourne, Vic, Australia St Vincents Hosp Melbourne Vic Australia Hosp, Melbourne, Vic, Australia
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 2, volume: 56, anno: 1999,
pagine: 133 - 141
SICI:
0003-990X(199902)56:2<133:HVIFPA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRUCTURAL BRAIN ABNORMALITIES; POSTTRAUMATIC-STRESS-DISORDER; TEMPORAL-LOBE STRUCTURES; BASAL GANGLIA; 1ST-EPISODE SCHIZOPHRENIA; P300 ABNORMALITIES; LIMBIC SYSTEM; MORPHOLOGY; ONSET; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Velakoulis, D MentalLockedRes Inst, Natl Hlth & Med Res Council, Schizophrenia Res Unit, Mental Hlth Res Inst Locked Bag 11 Parkville Vic Australia 3052
Citazione:
D. Velakoulis et al., "Hippocampal volume in first-episode psychoses and chronic schizophrenia - A high-resolution magnetic resonance imaging study", ARCH G PSYC, 56(2), 1999, pp. 133-141

Abstract

Background: It has been proposed that the hippocampus is a potential site for a neurodevelopmental lesion in schizophrenia. While smaller hippocampalvolumes have been described in chronic schizophrenia, there have been few magnetic resonance imaging studies in first-episode psychosis. Furthermore,no studies have examined the specificity of this finding to first-episode schizophrenia, compared with first-episode affective psychosis. Methods: Hippocampal and whole-brain volumes were estimated using high-resolution magnetic resonance imaging in 140 controls, 46 patients with chronic schizophrenia, and 32 patients with first-episode psychosis. Results: Patients with chronic schizophrenia and first-episode psychosis had significantly smaller hippocampal volumes as compared with controls. Within the first-episode group, both patients with schizophrenia/schizophreniform psychosis and those with affective psychosis had smaller left hippocampal volumes as compared with controls. Smaller right hippocampal volumes were associated with age and illness duration in patients with chronic schizophrenia. Hippocampal volumes were not correlated with age of illness onset or medication dosage in either patient group. Conclusions: These data show that smaller hippocam pal volumes are presentfrom the onset of illness. While these findings would support the neurodevelopmental model of schizophrenia, the finding of smaller left hippocampal volume in patients with first-episode schizophrenia and affective psychosisdoes not support the prediction that smaller hippocampi are specific to schizophrenia. The association of smaller right hippocampal volumes with increased illness duration in chronic schizophrenia suggests either that there is further neurodegeneration after illness onset or that bilateral small hippocampi predict chronicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:05:26