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Titolo:
Ossifying fibromyxoid tumour of soft parts: report of four cases includingone mediastinal and one infantile
Autore:
Ekfors, TO; Kulju, T; Aaltonen, M; Kallajoki, M;
Indirizzi:
Turku Univ, Dept Pathol, Turku 20520, Finland Turku Univ Turku Finland 20520 u Univ, Dept Pathol, Turku 20520, Finland N Karelian Cent Hosp, Dept Pathol, Joensuu, Finland N Karelian Cent Hosp Joensuu Finland osp, Dept Pathol, Joensuu, Finland
Titolo Testata:
APMIS
fascicolo: 12, volume: 106, anno: 1998,
pagine: 1124 - 1130
SICI:
0903-4641(199812)106:12<1124:OFTOSP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICOPATHOLOGICAL ANALYSIS;
Keywords:
ossifying fibromyxoid tumour; soft tissue tumour; mediastinum; immunohistochemistry; DNA cytometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Ekfors, TO Turku Univ, Dept Pathol, Turku 20520, Finland Turku Univ Turku Finland 20520 t Pathol, Turku 20520, Finland
Citazione:
T.O. Ekfors et al., "Ossifying fibromyxoid tumour of soft parts: report of four cases includingone mediastinal and one infantile", APMIS, 106(12), 1998, pp. 1124-1130

Abstract

Four cases of ossifying fibromyxoid tumour of soft parts an described. Oneof them was in the mediastinum, a hitherto unreported location of this rare neoplasm. Another was removed from the subcutaneous tissue of the head ofa two-year-old girl, the youngest patient so far described. A peculiar feature of this tumour was haphazard spindle cell groups showing smooth muscledifferentiation. One tumour was remarkably proliferative with 20 mitotic figures per 10 high power fields and 50% of cells positive for Ki-67 antigen. Immunohistochemical analysis revealed that all the tumours were diffuselypositive for vimentin, and focally for S-100-protein. In addition to this the infantile tumour expressed focal alpha-smooth muscle actin. desmin and glial fibrillary acidic protein, while the mediastinal tumour expressed only alpha-smooth muscle actin and the highly proliferative one expressed noneof these antigens. Background cells including histiocytes, lymphocytes andmast cells were numerous. DNA cytometry analysis using both static and flow methods showed that the mediastinal tumour contained two cell clones, while the others wen diploid. The proliferative fraction of cells (S plus G2 phases) was prominent in the proliferative and infantile tumours.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:49:33