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Titolo:
Prevalence and associations of MRI-demonstrated brain infarcts in elderly subjects with a history of transient ischemic attack - The Cardiovascular Health Study
Autore:
Bhadelia, RA; Anderson, M; Polak, JF; Manolio, TA; Beauchamp, N; Knepper, L; OLeary, DH;
Indirizzi:
Tufts Univ, New England Med Ctr, Dept Radiol, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Med Ctr, Dept Radiol, Boston, MA 02111 USA Cardiovasc Hlth Study Coordinating Ctr, Seattle, WA USA Cardiovasc Hlth Study Coordinating Ctr Seattle WA USA r, Seattle, WA USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA Johns Hopkins Radiol, Baltimore, MD USA Johns Hopkins Radiol Baltimore MDUSA Hopkins Radiol, Baltimore, MD USA Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Neurol, Pittsburgh, PA 15260 USA
Titolo Testata:
STROKE
fascicolo: 2, volume: 30, anno: 1999,
pagine: 383 - 388
SICI:
0039-2499(199902)30:2<383:PAAOMB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SILENT CEREBRAL INFARCTION; CAROTID ATHEROSCLEROSIS; CEREBROVASCULAR-DISEASE; COMPUTED-TOMOGRAPHY; ATRIAL-FIBRILLATION; OLDER ADULTS; STROKE; PROGNOSIS; LESIONS; EVALUATE;
Keywords:
cerebral infarction; cerebral ischemia, transient; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bhadelia, RA Tufts Univ, New England Med Ctr, Dept Radiol, 750 Washington St, Boston, MA Tufts Univ 750 Washington St Boston MA USA 02111 , Boston, MA
Citazione:
R.A. Bhadelia et al., "Prevalence and associations of MRI-demonstrated brain infarcts in elderly subjects with a history of transient ischemic attack - The Cardiovascular Health Study", STROKE, 30(2), 1999, pp. 383-388

Abstract

Background and Purpose - MRI is more sensitive than CT, but the significance of brain abnormalities seen on MR images obtained in older subjects withtransient ischemic attack (TIA) is not clear. We studied the prevalence and risk factors associated with MRI-demonstrated infarcts in elderly subjects with a history of TIA. Methods - Participants of the Cardiovascular Health Study, aged 65 years or more and without prior stroke, were studied with brain MRI (n = 3456). The prevalence of brain infarcts (greater than or equal to 3 mm) on MRI was determined in subjects with and without TIA, The cardiovascular risk factorsand clinical and subclinical cardiovascular disease associated with MRI infarcts were studied in subjects with TIA. Results - Subjects with TLA (n = 100) had a higher prevalence of MRI infarcts than subjects without TIA (46% versus 28%; P < 0.001), The unadjusted odds ratio for having MRI infarcts in subjects with TIA was 2.20 (95% CI, 1.47 to 3.30) and remained significantly elevated after adjustments for risk factors and cerebrovascular disease (odds ratio, 1.86; 95% CI, 1.23 to 2.83), In subjects with TIA, diastolic blood pressure (P = 0.01) and internal carotid artery intima-media thickness (P = 0.01) were the only factors predictive of the presence of MRI infarcts by stepwise logistic regression analysis. Conclusion - MRI infarcts are imaging manifestations of clinically important cerebrovascular disease in subjects with a history of TIA, given their increased prevalence and positive association with increased diastolic bloodpressure and internal carotid artery intima-media thickness.

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Documento generato il 25/11/20 alle ore 15:29:36