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Titolo:
Steroid eluting high impedance pacing leads decrease short and long term current drain: Results from a multicenter clinical trial
Autore:
Ellenbogen, KA; Wood, MA; Gilligan, DM; Zmijewski, M; Mans, D;
Indirizzi:
Virginiaond,monwealth Univ, Med Coll Virginia, Dept Med, Div Cardiol, Richm Virginia Commonwealth Univ Richmond VA USA 23298 Med, Div Cardiol, Richm McGuire Dept Vet Affairs Med Ctr, Richmond, VA USA McGuire Dept Vet Affairs Med Ctr Richmond VA USA d Ctr, Richmond, VA USA Medtron Inc, Minneapolis, MN USA Medtron Inc Minneapolis MN USAMedtron Inc, Minneapolis, MN USA
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 1, volume: 22, anno: 1999,
parte:, 1
pagine: 39 - 48
SICI:
0147-8389(199901)22:1<39:SEHIPL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRODE SURFACE-AREA; INITIAL EXPERIENCE;
Keywords:
pacemaker leads; pulse generator longevity; stimulation threshold;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ellenbogen, KA Virginia80053,nwealth Univ, Med Coll Virginia, Dept Med, Div Cardiol, POB 9 Virginia Commonwealth Univ POB 980053 Richmond VA USA 23298
Citazione:
K.A. Ellenbogen et al., "Steroid eluting high impedance pacing leads decrease short and long term current drain: Results from a multicenter clinical trial", PACE, 22(1), 1999, pp. 39-48

Abstract

Pacemaker lead technology has changed considerably over the past decades. The widespread use of low polarization highly porous electrodes and steroidelution electrodes has resulted in low chronic pacing thresholds, as well as a decrease in the incidence of exit block. Efforts to develop pacing leads with high impedance might theoretically lead to lower lead current drain, which is a component of battery capacity. Pulse generator longevity can be increased without sacrificing pacemaker capabilities if pacing current drain can be decreased. Decreasing the size of the stimulation electrode results in increased pacing impedance, and if pacing thresholds are unchanged, a decreased current drain is predicted by Ohm's law (I = V/R). There is limited data available on the pacing characteristics of large numbers of patients with high impedance leads, despite their recent general availability and increasing widespread use. This multicenter, controlled trial examined the differences in performance between standard steroid-eluting pacing leads in the atrium (Medtronic model 5524) and ventricle (Medtronic model 5024), and new high impedance steroid-eluting pacing leads in the atrium (Medtronic model 5534) and ventricle (Medtronic model 5034). Measurements of bipolarpacing thresholds at 2.5 V, pacing impedance, and sensing thresholds were determined within 24 hours of pacemaker implantation, and at 0.5, 2, 3, 6 and 12 months after pacemaker implantation in 609 patients. Pacing and sensing thresholds were similar for the control and high impedance leads at all times except for a slightly larger R wave with the high impedance leads at implantation and 12 months. The mean impedance of the high impedance pacingleads in the atrium and ventricle at 12 months wets 992 +/- 275 and 1,080 /- 220 Ohm, compared to 522 +/- 69 and 600 +/- 89 Ohm for the standard pacing leads in the atrium and ventricle (P less than or equal to 0.001 for the high impedance leads compared to standard leads in each chamber). The mean atrial lead current (measured at 2.5 V) at 12 months was 2.6 +/- 0.5 mA with the high impedance lead, and 4.9 +/- 0.7 mA with the standard lead in the atrium (P less than or equal to 0.002). In the ventricle, the mean lead current at 22 months was 2.4 +/- 0.4 mA with the high impedance pacing leadand 4.3 +/- 0.6 mA with the standard lead (P less than or equal to 0.002). High impedance leads are associated with lower lead current drain than standard pacing leads in the atrium and ventricle for up to 2 year. No clinically important differences in sensing characteristics was noted with the high impedance leads in the atrium or ventricle compared to standard pacing leads. High impedance leads may result in increased pulse generator longevity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:32:11