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Titolo:
Zinc modulation of AMPA receptors may be relevant to splice variants in carp retina
Autore:
Shen, Y; Yang, XL;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Physiol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China Chinese Acad Sci, Key Lab Neurobiol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 259, anno: 1999,
pagine: 177 - 180
SICI:
0304-3940(19990115)259:3<177:ZMOARM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHANNELS; NMDA;
Keywords:
zinc; AMPA receptor; cyclothiazide; PEPA; glutamate; horizontal cell; retina;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, XL ChinesePeoplesci, Shanghai Inst Physiol, 320 Yue Yang Rd, Shanghai 200031, Chinese Acad Sci 320 Yue Yang Rd Shanghai Peoples R China 200031
Citazione:
Y. Shen e X.L. Yang, "Zinc modulation of AMPA receptors may be relevant to splice variants in carp retina", NEUROSCI L, 259(3), 1999, pp. 177-180

Abstract

With the use of the whole-cell patch clamp technique, we examined effects of zinc on AMPA receptors of isolated carp retinal horizontal cells, predominantly consisting of flop splice variants. We found that zinc ranging from30 mu M to 1 mM failed to modulate glutamate-induced currents of these cells, which is clearly distinct from the results previously obtained in superior colliculus neurons and Xenopus ooctyes. Furthermore, glutamate responses remained unchanged when zinc was co-applied with PEPA, a flop variant-preferential AMPA receptor potentiator. With the co-application of cyclothiazide, a flip variant-preferential AMPA receptor potentiator, however, a dual effect could be observed: zinc potentiated glutamate responses at low concentrations, but inhibited them at higher concentrations. These results suggest that the action of zinc on AMPA receptors may be splice variant-relevant. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:04:18