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Titolo:
Dopamine D1 and D2 receptor agents and their interaction influence the synaptic density of the rat prefrontal cortex
Autore:
Sugahara, M; Shiraishi, H;
Indirizzi:
Univapankuba, Inst Clin Med Sci, Dept Psychiat, Tsukuba, Ibaraki 3058575, J Univ Tsukuba Tsukuba Ibaraki Japan 3058575 t, Tsukuba, Ibaraki 3058575, J
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 259, anno: 1999,
pagine: 141 - 144
SICI:
0304-3940(19990115)259:3<141:DDADRA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-CORTEX; SEROTONIN; MEMORY;
Keywords:
synapses; synaptic density; dopamine receptor; interaction; prefrontal cortex; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Shiraishi, H Univapankuba, Inst Clin Med Sci, Dept Psychiat, Tsukuba, Ibaraki 3058575, J Univ Tsukuba Tsukuba Ibaraki Japan 3058575 baraki 3058575, J
Citazione:
M. Sugahara e H. Shiraishi, "Dopamine D1 and D2 receptor agents and their interaction influence the synaptic density of the rat prefrontal cortex", NEUROSCI L, 259(3), 1999, pp. 141-144

Abstract

Recent findings indicate that some monoamines contribute to synaptic maintenance. We examined the synaptic density of the prefrontal cortex of rats with the single or combined administration of DI and D2 antagonists and agonists. When each agent was administered individually, we observed a significant difference in synaptic density. This indicates that dopamine regulates synaptic maintenance. With the combined administration of antagonists or agonists at high dosages, a synergistic effect was observed. With the combined administration of a D1 antagonist and D2 agonist or a D1 agonist and D2 antagonist, a low dose of the D2 receptor drug enhanced the effect of the DIreceptor drug. The DI receptor drug offset the effect of the high dose of D2 receptor drug, suggesting the possibility that the D1 receptor family isessential for synaptic maintenance. (C) 1999 Elsevier Science Ireland Ltd. AII rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:30:40