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Titolo:
Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons
Autore:
Svenningsson, P; Fourreau, L; Bloch, B; Fredholm, BB; Gonon, F; Le Moine, C;
Indirizzi:
UniveBordeaux 2, UMR CNRS 5541, Lab Histol Embryol, F-33076 Bordeaux, Franc Univ Bordeaux 2 Bordeaux France F-33076 Embryol, F-33076 Bordeaux, Franc Karolinska Inst, Dept Physiol & Pharmacol, Sect Mol Neuropharmacol, S-17177 Karolinska Inst Stockholm Sweden S-17177 ect Mol Neuropharmacol, S-17177
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 89, anno: 1999,
pagine: 827 - 837
SICI:
0306-4522(199903)89:3<827:OTMODA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT STRIATAL NEURONS; BASAL GANGLIA; MESSENGER-RNA; 6-HYDROXYDOPAMINE-LESIONED RATS; RECEPTOR ANTAGONISTS; A(2A) RECEPTORS; D2-DOPAMINE RECEPTORS; MATRIX COMPARTMENTS; ROTATIONAL BEHAVIOR; PARKINSONS-DISEASE;
Keywords:
dopamine release; dopamine D-2 receptors; adenosine A(2A) receptors; striatum; c-fos mRNA; in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Le Moine, C Univ33076eaux 2, UMR CNRS 5541, Lab Histol Embryol, 146 Rue Leo Saignat, F- Univ Bordeaux 2 146 Rue Leo Saignat Bordeaux France F-33076 -
Citazione:
P. Svenningsson et al., "Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons", NEUROSCIENC, 89(3), 1999, pp. 827-837

Abstract

The impulse flow-dependent dopamine release in the striatum was acutely blocked by unilateral lesion of the medial forebrain bundle with 6-hydroxydopamine. Within 45 min this disruption reduced the striatal extracellular dopamine levels by 80% as determined by in vivo voltammetry. A strong induction of c-fos messenger RNA was detected in the ipsilateral dorsolateral striatum 75min after 6-hydroxydopamine injection by in situ hybridization. Double labelling demonstrates that this induction was confined to neurons expressing the dopamine D-2 receptor messenger RNA. At this time-point, there were no changes in the striatal levels of either tyrosine hydroxylase immunoreactivity or dopamine D-2 receptor messenger RNA. The c-fos messenger RNA expression induced by acute 6-hydroxydopamine injection was abolished by intraperitoneal pretreatment with the dopamine D2 receptor agonist, quinelorane(2 mg/kg) and strongly reduced by administration of the selective adenosine A,, receptor antagonist SCH-58261 (5 mg/kg). The results reported here show, by using a novel methodological approach, that an acute decrease of dopamine release causes an induction of c-fos messenger RNA in dopamine D-2 receptor-containing striatopallidal neurons. This, together with previous findings, demonstrates that the c-fos gene expression is tonically inhibited by the impulse flow-dependent dopamine release via D-2 receptors. In addition, this study provides evidence that endogenous adenosine, acting via adenosine A,receptors, induces striatal c-fos messenger RNA when extracellular dopamine levels are strongly reduced. Thus endogenous dopamine and adenosine exert opposite effects on the activity of theD-2-containing striatopallidal neurons. (C) 1999 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 22/09/20 alle ore 12:13:54