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Titolo:
Stress-induced release of anterior pituitary hormones: Effect of H-3 receptor-mediated inhibition of histaminergic activity or posterior hypothalamiclesion
Autore:
Knigge, U; Soe-Jensen, P; Jorgensen, H; Kjaer, A; Moller, M; Warberg, J;
Indirizzi:
Univ200penhagen, Panum Inst, Dept Med Physiol, Div Endocrinol & Metab, DK-2 Univ Copenhagen Copenhagen Denmark N ysiol, Div Endocrinol & Metab, DK-2 Univ Copenhagen, Panum Inst, Inst Med Anat, DK-2200 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2200 , DK-2200 Copenhagen, Denmark Univ Copenhagen, Rigshosp, Dept Surg C, DK-2200 Copenhagen N, Denmark UnivCopenhagen Copenhagen Denmark N rg C, DK-2200 Copenhagen N, Denmark
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 1, volume: 69, anno: 1999,
pagine: 44 - 53
SICI:
0028-3835(199901)69:1<44:SROAPH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOMELANOCORTIN-DERIVED PEPTIDES; TUBEROMAMMILLARY NUCLEUS REGION; MELANOCYTE-STIMULATING HORMONE; RAT-BRAIN CORTEX; BETA-ENDORPHIN; NEUROTOXIC LESIONS; ETHER STRESS; NEUROTRANSMITTER REGULATION; PARAVENTRICULAR LESIONS; LUTEINIZING-HORMONE;
Keywords:
histamine receptors; corticotropin; beta-endorphin; prolactin; adrenal steroids; stress; endotoxin; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Knigge, U Univ Copenhagen, Panum Inst, Dept Med Physiol, Div Endocrinol & Metab, Bldg Univ Copenhagen Bldg 12-3,Blegdamsvej 3 C Copenhagen Denmark N
Citazione:
U. Knigge et al., "Stress-induced release of anterior pituitary hormones: Effect of H-3 receptor-mediated inhibition of histaminergic activity or posterior hypothalamiclesion", NEUROENDOCR, 69(1), 1999, pp. 44-53

Abstract

The effect of stress- or lipopolysaccharide (LPS) endotoxin-induced release of ACTH, beta-endorphin (beta-END) and prolactin (PRL) was investigated in two groups of conscious male rats: (1) Rats pretreated with different H-3receptor agonists, which inhibit neuronal histamine (HA) synthesis and release, and (2) rats with bilateral posterior hypothalamic lesion, which destroys the histaminergic perikarya exclusively localized in the mammillary nuclei. The Hg receptor agonists R(alpha)methyl-HA, BP 2-94 or Imetit injected intraperitoneally tip) had no effect on basal secretion of ACTH or PRL but inhibited the ACTH and PRL responses to restraint stress and the ACTH response to LPS endotoxin. LPS had no effect on PRL secretion. The inhibitory effect of the agonists was prevented by prior ip administration of the He receptor antagonist thioperamide. Bilateral lesion of the posterior hypothalamus inhibited the ACTH, beta-END and PRL responses to restraint stress, ether stress and LPS endotoxin, whereas sham operation had no effect comparedto nonoperated control rats. In addition, posterior hypothalamic lesion inhibited the PRL response but not the ACTH and B-END responses to activationof serotonergic neurons induced by ip administration of the 5-HT precusor 5-hydroxytryptophan in combination with the 5-HT re-uptake inhibitor fluoxetine. Thus, serotonergic pathways were not damaged by the lesions. The present results support our previous findings that inhibition of neuronal HA synthesis by alpha-fluoromethyl-histidine as well as blockade of H-1or H-2 receptors inhibit the ACTH, beta-END and PRL responses to stress and LPS endotoxin and further substantiate an important role of histaminergicneurons in the mediation of the stress-induced release of pituitary stresshormones. Furthermore, in accordance with our previous findings, the lesion experiments indicated the existence of an interaction between the histaminergic and serotonergic system in regulation of the stress- and LPS-inducedPRL release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 11:54:48