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Titolo:
Attenuation of morphine-induced behavioral changes in rodents by D- and L-glucose
Autore:
Talley, CP; Arankowsky-Sandoval, G; McCarty, R; Gold, PE;
Indirizzi:
Univ Virginia, Dept Psychol, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 1, volume: 71, anno: 1999,
pagine: 62 - 79
SICI:
1074-7427(199901)71:1<62:AOMBCI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION; MEDIAL SEPTUM; MEMORY; INJECTIONS; TRANSPORT; BRAIN; RATS; PERFORMANCE; ENHANCEMENT; IMPAIRMENTS;
Keywords:
D-glucose; L-glucose; memory modulation; spontaneous alternation; medial septum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Gold, PE Univ Virginia, Dept Psychol, 102 Gilmer Hall, Charlottesville, VA22903 USA Univ Virginia 102 Gilmer Hall Charlottesville VA USA 22903 03 USA
Citazione:
C.P. Talley et al., "Attenuation of morphine-induced behavioral changes in rodents by D- and L-glucose", NEUROBIOL L, 71(1), 1999, pp. 62-79

Abstract

Administration of D-glucose enhances learning and memory in several tasks and also attenuates memory impairments and other behavioral effects of several drugs, including morphine. The present experiment compared the effects of peripherally administered D-glucose with those of L-glucose, a stereoisomer of D-glucose that is not metabolized and does not readily cross the blood-brain barrier. Like D-glucose, though at somewhat different doses; peripherally administered L-glucose attenuated morphine-induced deficits in spontaneous alternation performance in rats and mice and attenuated morphine-induced hyperactivity in mice. L-Glucose did not raise circulating levels of plasma D-glucose, suggesting that the effects of L-glucose are not secondary to increased availability of D-glucose. Using direct injections of D- andL-glucose and morphine into the medial septum of rats, the findings indicate that D-glucose but not L-glucose attenuated morphine-induced deficits inspontaneous alternation performance;indeed, intraseptal injections of L-glucose alone impaired spontaneous alternation performance. These findings suggest that peripheral L-glucose antagonizes morphine-induced behavioral effects by a peripheral signaling mechanism, one distinct from the mechanisms that mediate at least some of the effects of D-glucose on brain function. (C) 1999 Academic Press.

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Documento generato il 13/07/20 alle ore 17:42:23