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Titolo:
Ethanol discrimination in the rat: lack of modulation by restraint stress and memantine
Autore:
Koros, E; Kostowski, W; Danysz, W; Bienkowski, P;
Indirizzi:
Instsaw,chiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, PL-02957 War Inst Psychiat & Neurol Warsaw Poland PL-02957 Nervous Syst, PL-02957 War Merz & Co, Dept Pharmacol Res, D-60048 Frankfurt, Germany Merz & Co Frankfurt Germany D-60048 acol Res, D-60048 Frankfurt, Germany
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 2, volume: 359, anno: 1999,
pagine: 117 - 122
SICI:
0028-1298(199902)359:2<117:EDITRL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; NMDA RECEPTOR ANTAGONISTS; GATED ION CHANNELS; STIMULUS PROPERTIES; INDUCED INCREASE; ALCOHOL; RELEASE; DRINKING; INTOXICATION; INVOLVEMENT;
Keywords:
ethanol; restraint stress; NMDA receptor complex; memantine; drug discrimination; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Bienkowski, P Instgosychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, Al Sobieskie Inst Psychiat & Neurol Al Sobieskiego 1-9 Warsaw Poland PL-02957
Citazione:
E. Koros et al., "Ethanol discrimination in the rat: lack of modulation by restraint stress and memantine", N-S ARCH PH, 359(2), 1999, pp. 117-122

Abstract

There is a large body of experimental evidence that both stress and N-methyl-D-aspartate (NMDA) receptor antagonists may alter acute behavioural effects of ethanol. Notably, an uncompetitive, low-affinity NMDA receptor antagonist, memantine, has been recently claimed to possess anti-craving properties in rats with a long-term history of ethanol consumption. The aim of thepresent study was to assess the effects of restraint stress and memantine on the dose-response curve of ethanol discrimination. Rats were trained to discriminate 1 g/kg ethanol from saline in the two-lever drug discrimination procedure. When ethanol discrimination was acquired, the subjects were exposed to 30-min sessions of acute restraint stress, and different doses of ethanol (0.25, 0.5 or 1 g/kg) or saline were administered. In subsequent experiments the effects of memantine (2.25 or 4.5 mg/kg) on the cueing effects of ethanol were tested. Neither the stress sessions nor memantine influenced the ethanol discrimination dose-response curve. Moreover, the stress did not alter the rate of responding. However, both doses of memantine tendedto increase the rate of responding when given in combination with lower doses of ethanol (0.25-0.5 g/kg). In contrast, 4.5 mg/kg memantine decreased the response rate when combined with 1 g/kg ethanol. These results suggest that: (1) pre-exposure to acute restraint stress or memantine does not affect the dose-response curve of ethanol discrimination; (2) memantine given in combination with low doses of ethanol may stimulate operant behaviour in the food-reinforced drug discrimination procedure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:43:23