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Titolo:
Expression of neurotrophin mRNAs in the dorsal root ganglion after spinal nerve injury
Autore:
Shen, H; Chung, JM; Chung, K;
Indirizzi:
Univ Texas, Med Branch, Inst Marine Biomed, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 Marine Biomed, Galveston, TX 77555 USA Univ Texas, Med Branch, Dept Anat & Neurosci, Galveston, TX 77555 USA UnivTexas Galveston TX USA 77555 nat & Neurosci, Galveston, TX 77555 USA Univ Texas, Med Branch, Dept Physiol & Biophys, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 siol & Biophys, Galveston, TX 77555 USA
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 2, volume: 64, anno: 1999,
pagine: 186 - 192
SICI:
0169-328X(19990205)64:2<186:EONMIT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE AXONAL-TRANSPORT; PRIMARY SENSORY NEURONS; GROWTH-FACTOR SYNTHESIS; MESSENGER-RNA; SCIATIC-NERVE; SYMPATHETIC-GANGLIA; DISTINCT PATTERNS; RAT; BDNF; NGF;
Keywords:
BDNF; neuropathic pain; NGF; NT-3; RPA; spinal nerve ligation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, K Univ555xas, Med Branch, Inst Marine Biomed, 301 Univ Blvd, Galveston, TX 77 Univ Texas 301 Univ Blvd Galveston TX USA 77555 Galveston, TX 77
Citazione:
H. Shen et al., "Expression of neurotrophin mRNAs in the dorsal root ganglion after spinal nerve injury", MOL BRAIN R, 64(2), 1999, pp. 186-192

Abstract

Neurotrophins have specificity toward distinct subpopulations of dorsal root ganglion (DRG) neurons with different neurotrophin receptors. It has been suggested that neurotrophins also play important roles in mature DRG neurons after injury. In the present study, we examined the expression of nervegrowth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) mRNAs in the DRG after a peripheral nerve injury. The data showed that following a spinal nerve ligation, the level of NGF mRNA increased 3 times over the normal level and was maintained at a high level for a period of 3 weeks. The induction of BDNF mRNA was brief(lasting less than 3 days) and lesser in quantity (similar to 1.7 times increase) compared to NGF expression. The expression of NT-3 mRNA was not detected either in normalor nerve injured rats. Results suggest that different neurotrophins play different functional roles in the DRG after spinal nerve injury. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:22:16