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Titolo:
Two blood pressure cardiac mass quantitative trait loci on Chromosome 3 inDahl rats
Autore:
Cicila, GT; Choi, C; Dene, H; Lee, SJ; Rapp, JP;
Indirizzi:
Med Coll Ohio, Dept Physiol & Mol Med, Toledo, OH 43614 USA Med Coll OhioToledo OH USA 43614 Physiol & Mol Med, Toledo, OH 43614 USA
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 2, volume: 10, anno: 1999,
pagine: 112 - 116
SICI:
0938-8990(199902)10:2<112:TBPCMQ>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
OLIGONUCLEOTIDE-PRIMED PCR; LINKAGE MAP; CONGENIC STRAINS; RENIN ALLELES; GENE; HYPERTENSION; COSEGREGATION; ENDOTHELIN; RESISTANT; MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Cicila, GT Medve,ll Ohio, Dept Physiol & Mol Med, Block Hlth Sci Bldg,3035Arlington A Med Coll Ohio Block Hlth Sci Bldg,3035 Arlington Ave Toledo OHUSA 43614
Citazione:
G.T. Cicila et al., "Two blood pressure cardiac mass quantitative trait loci on Chromosome 3 inDahl rats", MAMM GENOME, 10(2), 1999, pp. 112-116

Abstract

Interval mapping was used to identify putative quantitative trait loci (QTL) for blood pressure and cardiac mass on Chromosome (Chr)3 in F-1(S x R)x S population of 150 rats raised on an 8% NaCl diet. Two genetic markers 95.7 cM apart, D3Wox3 and D3Mco5 (tightly linked to Edn3), showed "suggestive"linkage to blood pressure (LOD = 2.0 and 1.8 respectively). In addition. D3Wox3 showed "suggestive" linkage to heart weight (LOD = 2.5), and D3Mco5 showed ''suggestive'' linkage to body weight-adjusted heart weight (LOD = 2.1). Congenic rats (designated S.R-Edn3) were constructed by introgressing the R-rat Edn3 allele (and flanking loci) into the S strain. On a 2% NaCl diet, S.R-Edn3 rats had lower blood pressure (21.4 mm Hg, P = 0.0005) and heart weight (59 mg. P = 0.0038) compared with S rats, confirming the existence of a blood pressure QTL on Chr 3 near Edn3 even though QTL linkage analysis of blood pressure did not achieve stringent statistical criteria for significance. The results of the congenic experiment and the large distance between the two putative QTL suggest the presence of at least two independentblood pressure/cardiac mass QTL detectable on Chr 3 in the Dahl rat model of genetic hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:23:25