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Titolo:
Detection of fluoxetine in brain, blood, liver and hair of rats using gas chromatography mass spectrometry
Autore:
Lefebvre, M; Marchand, M; Horowitz, JM; Torres, G;
Indirizzi:
SUNY Buffalo, Dept Psychol, Behav Neurosci Program, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 Neurosci Program, Buffalo, NY 14260 USA Ctr Toxicol Quebec, Quebec City, PQ G1V 4G2, Canada Ctr Toxicol Quebec Quebec City PQ Canada G1V 4G2 City, PQ G1V 4G2, Canada
Titolo Testata:
LIFE SCIENCES
fascicolo: 9, volume: 64, anno: 1999,
pagine: 805 - 811
SICI:
0024-3205(19990122)64:9<805:DOFIBB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN; DRUGS; ANTIDEPRESSANT; MECHANISMS; ABUSE;
Keywords:
serotonin; antidepressant; striatum; hypothalamus; raphe nucleus; hair;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Torres, G SUNY14260alo, Dept Psychol, Behav Neurosci Program, Park Hall, Buffalo, NY SUNY Buffalo Park Hall Buffalo NY USA 14260 rk Hall, Buffalo, NY
Citazione:
M. Lefebvre et al., "Detection of fluoxetine in brain, blood, liver and hair of rats using gas chromatography mass spectrometry", LIFE SCI, 64(9), 1999, pp. 805-811

Abstract

This study reports the measurements of fluoxetine in discrete brain regions, blood, liver and hair of male rats injected with 10 mg/kg fluoxetine HClfor 15 consecutive days. Concentrations of the antidepressant were obtained by gas chromatography-mass spectrometry (GC-MS) methodology. In brain, fluoxetine levels were unevenly distributed, with the raphe nucleus containing the highest amounts relative to the hypothalamus or striatum. Fluoxetine was also measured in blood and Liver roughly paralleling those ratios described in previous rodent studies. Of potential interest, fluoxetine was found to accumulate in rat hair after chronic treatment. Detection of fluoxetine in hair by GC-MS could be used as a marker for probative analyses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:49:14