Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains
Autore:
Albers, JJ; Pitman, W; Wolfbauer, G; Cheung, MC; Kennedy, H; Tu, AY; Marcovina, SM; Paigen, B;
Indirizzi:
Univ Washington, NW Lipid Res Labs, Dept Med, Seattle, WA 98103 USA Univ Washington Seattle WA USA 98103 abs, Dept Med, Seattle, WA 98103 USA Jackson Lab, Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor ME USA 04609Jackson Lab, Bar Harbor, ME 04609 USA
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 2, volume: 40, anno: 1999,
pagine: 295 - 301
SICI:
0022-2275(199902)40:2<295:RBPTPA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-PLASMA; LIPOPROTEIN METABOLISM; TRANSGENIC MICE; GENETIC-FACTORS; DIETARY-FAT; ATHEROSCLEROSIS; CHOLESTEROL; RESPONSIVENESS; INSIGHTS; DISEASE;
Keywords:
phospholipid transfer protein; high density lipoproteins; phospholipid; high fat diet; high cholesterol diet; inbred mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Albers, JJ Univ8103hington, NW Lipid Res Labs, Dept Med, 2121 N 35th St, Seattle, WA 9 Univ Washington 2121 N 35th St Seattle WA USA 98103 attle, WA 9
Citazione:
J.J. Albers et al., "Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains", J LIPID RES, 40(2), 1999, pp. 295-301

Abstract

Because of the paucity of data on phospholipid transfer protein (PLTP) activity and lipoprotein phospholipid in mouse strains, plasma PLTP activity (PLTA), plasma phospholipid and cholesterol, HDL phospholipid and cholesterol, and HDL size distribution were determined in 15 inbred mouse strains. The 15 inbred mouse strains differed in their relatedness to one another and consisted of six largely unrelated groups: Castaneus, Swiss, C57BL, AKR, DBA, and NZB. Lipid and PLTA analyses were performed on plasma pools from male and female mice that had fasted for 4 h prior to blood draw. Among the representative unrelated strains fed the chow diet, there was a highly significant relationship between PLTA and plasma phospholipid (r(s) = 0.727, P < 0.01), HDL phospholipid (r(s) = 0.762, P < 0.01), HDL cholesterol (r(s) = 0.699, P < 0.02), percentage of large HDL particles (r(s) = 0.699, P < 0.02), and HDL peak size (r(s) = 0.776, P < 0.01). Similar results were obtainedamong these strains fed a high fat, high cholesterol diet. PLTA increased in all strains fed the high fat diet ((x) over bar = 94%, range 6 to 221%). Strain SM having relatively low PLTA and HDL was crossed with strain NZB having high PLTA and HDL. The F1 progeny from this cross were backcrossed tostrain SM and 41 male backcross progeny collected. Among these individual backcrossed animals, PLTA was highly correlated with plasma phospholipid (r(s) = 0.508, P = 0.002), HDL phospholipid (r(s) = 0.566, P < 0.001), HDL cholesterol (r(s) = 0.532, P < 0.001), and percentage of large HDL particles (r(s) = 0.446, P = 0.020). Therefore, we conclude that PLTP is a determinant of HDL level and size in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:54:33