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Titolo:
Sensitization to Alternaria and Cladosporium in asthmatic patients and itsin vitro diagnostic confirmation
Autore:
Resano, A; Sanz, ML; Oehling, A;
Indirizzi:
Univainvarra Clin, Dept Allergy & Clin Immunol, Fac Med, Pamplona 31080, Sp Univ Navarra Clin Pamplona Spain 31080 unol, Fac Med, Pamplona 31080, Sp
Titolo Testata:
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY
fascicolo: 6, volume: 8, anno: 1998,
pagine: 353 - 358
SICI:
1018-9068(199811/12)8:6<353:STAACI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOMATED HISTAMINE ANALYSIS; SKIN PRICK TEST; MOLD ALLERGY; WHOLE-BLOOD; RELEASE; INVITRO; RAST; IMMUNOTHERAPY; PREVALENCE; HERBARUM;
Keywords:
Alternaria; Cladosporium; airborne moulds; in vitro diagnostic tests; specific IgE; histamine release test; diagnostic reliability; bronchial asthma; rhinitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Oehling, A Univplonarra Clin, Dept Allergy & Clin Immunol, Fac Med, Apartado 4209, Pam Univ Navarra Clin Apartado 4209 Pamplona Spain 31080 4209, Pam
Citazione:
A. Resano et al., "Sensitization to Alternaria and Cladosporium in asthmatic patients and itsin vitro diagnostic confirmation", J INVES ALL, 8(6), 1998, pp. 353-358

Abstract

In order to determine the prevalence of airborne mould sensitization and the reliability of the in vitro diagnostic techniques in daily practice (antigen-specific IgE and histamine release test), we performed a 3-year study in 2,200 patients diagnosed with rhinosinusitis and/or bronchial asthma. Wefound mould sensitization in 101 patients, 20% of whom presented monosensitization against airborne moulds, and the rest associated other sensitizations as follows: 53.7% against Dermatophagoides pteronyssinus, 45% against grass pollen and 30% against Olea europea. The most frequently involved moulds in our patients were Alternaria and Cladosporium. Seventy-six percent ofthe patients presented sensitization against Alternaria, 56% of whom were monosensitized, 26% presented co-sensitization to Cladosporium and the remainder were sensitive to more than two moulds. Regarding Cladosporium, the percentage of patients was similar (66%), although only 23% were monosensitized and 46% presented an associated sensitization against Alternaria. We also observed a correlation between skin tests and both in vitro diagnostic techniques, with a relative sensitivity of the specific IgE determination compared to the skin test of 98% against Alternaria and 90.4% against Cladosporium, whereas the relative sensitivity of the histamine release test was 97.4% for Alternaria and 85% for Cladosporium. In conclusion, we think that in order to confirm the etiopathogenesis of the airborne moulds and before an immunotherapy treatment is indicated, the positive skin reactions shouldbe confirmed by means of reliable laboratory diagnostic techniques, such as antigen-specific IgE determination and histamine release test.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:14:14