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Titolo:
Decreased heart rate variability in patients with type 1 diabetes mellitusis related to arterial wall stiffness
Autore:
Jensen-Urstad, K; Reichard, P; Jensen-Urstad, M;
Indirizzi:
KarolinskaStockholm,t Emergency & Cardiovasc Med, Karolinska Inst, S-17176Karolinska Hosp Stockholm Sweden S-17176 c Med, Karolinska Inst, S-17176 Karolinska Hosp, Dept Cardiol, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 diol, S-10401 Stockholm, Sweden Soder Sjukhuset, Dept Internal Med, S-10064 Stockholm, Sweden Soder Sjukhuset Stockholm Sweden S-10064 Med, S-10064 Stockholm, Sweden
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 1, volume: 245, anno: 1999,
pagine: 57 - 61
SICI:
0954-6820(199901)245:1<57:DHRVIP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SINUS ARRHYTHMIA; ACUTE MYOCARDIAL-INFARCTION; FREQUENCY-DOMAIN MEASURES; POWER SPECTRAL-ANALYSIS; PERIOD VARIABILITY; CONSCIOUS HUMANS; BLOOD-PRESSURE; MORTALITY; ATHEROSCLEROSIS; DISEASE;
Keywords:
arterial baroreceptors; arterial wall stiffness; atherosclerosis; heart rate variability; insulin-dependent diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Jensen-Urstad, K KarolinskaStockholm,t Emergency & Cardiovasc Med, Karolinska Inst, S-17176 Karolinska Hosp Stockholm Sweden S-17176 Inst, S-17176
Citazione:
K. Jensen-Urstad et al., "Decreased heart rate variability in patients with type 1 diabetes mellitusis related to arterial wall stiffness", J INTERN M, 245(1), 1999, pp. 57-61

Abstract

Objective. Low heart rate variability (HRV) is, in several patient groups,related to poor prognosis. The underlying mechanisms are still unclear. The aim was to study if there is a relationship between HRV, which is a measure of baroreceptor function, and atherosclerosis. Design. The relationship between heart rate variability and carotid arterial wall stiffness was studied in subjects with type 1 diabetes mellitus in which autonomic dysfunction and early atherosclerosis are common. HRV was assessed from power spectral analysis of 24-h Holter recordings and arterialwall stiffness was assessed from an ultrasound study of the right common carotid artery. Setting. A university hospital. Subjects. Fifty-nine patients (41 +/- 8 years) from the Stockholm DiabetesIntervention Study (SDIS) were investigated. These patients were randomized to intensified conventional treatment or standard treatment approximately12 years before this study. Results, Patients with stiffer arteries had lower HRV in all spectral bands (r = -0.32 to -0.40, P = 0.06-0.001). This relation remained on correcting for age. All spectral parameters of HRV correlated with the mean HbA1c from 10 years of study (r = -0.37 to -0.40, P = 0.004-0.001). Conclusions. In patients with type 1 diabetes mellitus, heart rate variability and arterial wall stiffness are related to each other. The results suggests that the autonomic nervous system could be a link between diabetes and vascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:23:47