Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development
Autore:
Di Santo, JP; Aifantis, I; Rosmaraki, E; Garcia, C; Feinberg, J; Fehling, HJ; Fischer, A; von Boehmer, H; Rocha, B;
Indirizzi:
Hop Necker Enfants Malad, INSERM, U429, F-75743 Paris, France Hop Necker Enfants Malad Paris France F-75743 429, F-75743 Paris, France CHU Necker Enfants Malad, INSERM, U345, F-75730 Paris, France CHU Necker Enfants Malad Paris France F-75730 345, F-75730 Paris, France CHU Necker Enfants Malad, INSERM, U373, F-75730 Paris, France CHU Necker Enfants Malad Paris France F-75730 373, F-75730 Paris, France Basel Inst Immunol, CH-4005 Basel, Switzerland Basel Inst Immunol Basel Switzerland CH-4005 CH-4005 Basel, Switzerland
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 3, volume: 189, anno: 1999,
pagine: 563 - 573
SICI:
0022-1007(19990201)189:3<563:TCCRGC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; INTERLEUKIN-7 RECEPTOR; DEFICIENT MICE; BETA-CHAIN; C-KIT; LYMPHOID DEVELOPMENT; THYMOCYTE DIFFERENTIATION; GENE REARRANGEMENT; IN-VIVO; EXPRESSION;
Keywords:
thymus; interleukin; lymphocyte; development; knockout;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Di Santo, JP HopF-75743 Enfants Malad, INSERM, U429, Pavillon Kirmisson,149 Rue Sevres, Hop Necker Enfants Malad Pavillon Kirmisson,149 Rue Sevres Paris France F-75743
Citazione:
J.P. Di Santo et al., "The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development", J EXP MED, 189(3), 1999, pp. 563-573

Abstract

Intracellular signals emanating from cytokine and antigen receptors are integrated during the process of intrathymic development. Still, the relativecontributions of cytokine receptor signaling to pre-T cell receptor (TCR and TCR-mediated differentiation remain undefined. Interleukin (IL)-7 interactions with its cognate receptor complex (IL-7R alpha coupled to the commoncytokine receptor gamma chain, gamma(c)) play a dominant role in early thymopoiesis. However, alpha/beta T cell development in IL-7-, IL-7R alpha-, and gamma(c)-deficient mice is only partially compromised, suggesting that additional pathways can rescue alpha/beta T lineage cells in these mice. We have investigated the potential interdependence of gamma(c)- and pre-TCR-dependent pathways during intrathymic alpha/beta T cell differentiation. We demonstrate that gamma(c)-dependent cytokines do not appear to be required for normal pre-TCR function, and that the rate-limiting step in alpha/beta Tcell development in gamma(c)(-) mice does not involve TCR-beta chain rearrangements, but rather results from poor maintenance of early thymocytes. Moreover, mice double mutant for both gamma(c) and pre-T alpha show vastly reduced thymic cellularity and a complete arrest of thymocyte differentiationat the CD44(+)CD25(+) cell stage. These observations demonstrate that the pre-TCR provides the gamma(c)-independent signal which allows alpha/beta T cell development in gamma(c)(-) mice. Thus, a series of overlapping signalsderived from cytokine and T cell receptors guide the process of alpha/betathymocyte development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:03:59