Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Vasoconstrictor effects of various melatonin analogs on the rat tail artery in the presence of phenylephrine
Autore:
Bucher, B; Gauer, F; Pevet, P; Masson-Pevet, M;
Indirizzi:
UnivF-67401Pasteur Strasbourg 1, Lab Pharmacol & Physiol Cellulaire, CNRS,Univ Louis Pasteur Strasbourg 1 Illkirch Graffenstaden France F-67401 S, Univaden,s Pasteur Strasbourg 1, CNRS, UMR 7518, F-67401 Illkirch Graffenst Univ Louis Pasteur Strasbourg 1 Illkirch Graffenstaden France F-67401 st
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 2, volume: 33, anno: 1999,
pagine: 316 - 322
SICI:
0160-2446(199902)33:2<316:VEOVMA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASORELAXING ACTION; CAUDAL ARTERY; PINEAL-GLAND; RECEPTORS; NORADRENALINE; BRAIN; AORTA; REPRODUCTION; ENDOTHELIUM; EXPRESSION;
Keywords:
melatonin; isolated rat tail artery; melatonin antagonist; vasoconstriction; Mel(1a) mRNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Bucher, B UnivERSuis Pasteur Strasbourg 1, Lab Pharmacol & Physiol Cellulaire, CNRS, Univ Louis Pasteur Strasbourg 1 ERS 653,BP 24 Illkirch Graffenstaden France F-67401
Citazione:
B. Bucher et al., "Vasoconstrictor effects of various melatonin analogs on the rat tail artery in the presence of phenylephrine", J CARDIO PH, 33(2), 1999, pp. 316-322

Abstract

We performed a pharmacologic analysis of the increase in perfusion pressure induced by melatonin and related analogues in the perfused rat tail artery precontracted by 1 mu M phenylephrine. Melatonin, 2-iodomelatonin, 6-chloromelatonin, and 820098 (N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide) produced a concentration-dependent enhancement of the vasoconstrictor response evoked by 1 mu M phenylephrine with a rank order of potency compatible with the pharmacologic profile defined for high-affinity melatonin receptors. Melatonin had no effect on electrically induced [H-3]noradrenaline release, but the neurogenic vasoconstriction was increased at melatonin concentrationsof 100 and 300 nM. Increasing concentrations of the naphthalenic-based antagonist S20928 (N-[2(1 -naphthyl)ethyl]cyclobutanecarboxamide) caused a parallel rightward shift in the melatonin concentration-response curve withoutdepressing the maximal response. The pA(2) value of S20928 was 7.01 +/- 0.08. Luzindole, 1 mu M, an antagonist of Mel(1b) melatonin receptors, was without effect on melatonin-induced responses. By using reverse transcription-polymerase chain reaction (RT-PCR), we found that messenger RNA (mRNA) encoding for Mel(1a) is transcribed in the rat tail artery. In conclusion, theresults show that melatonin produced an enhancement of the contractile response elicited by phenylephrine in the perfused rat tail artery. This vasoconstrictor response appears to be mediated through activation of Mel(1a) receptors located on smooth-muscle cells. No evidence for an action of melatonin on either the endothelium or sympathetic nerve endings was found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/08/20 alle ore 10:14:32