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Titolo:
Effects of sex steroids and growth factors on invasive activity and 5 '-deoxy-5-fluorouridine sensitivity in ovarian adenocarcinoma OMC-3 cells
Autore:
Ueda, M; Fujii, H; Yoshizawa, K; Kumagai, K; Ueki, K; Terai, Y; Yanagihara, T; Ueki, M;
Indirizzi:
Osaka Med Coll, Dept Obstet & Gynecol, Takatsuki, Osaka 5698686, Japan Osaka Med Coll Takatsuki Osaka Japan 5698686 atsuki, Osaka 5698686, Japan Nipponanayaku Co Ltd, Pharmaceut Grp, Res Labs, Kita Ku, Tokyo 1150042, Jap Nippon Kayaku Co Ltd Tokyo Japan 1150042 bs, Kita Ku, Tokyo 1150042, Jap Nippon1,oche Co Ltd, Oncol Business Dept, Div Pharmaceut,Med Planning SectNippon Roche Co Ltd Osaka Japan 5410046 Div Pharmaceut,Med Planning Sect
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 12, volume: 89, anno: 1998,
pagine: 1334 - 1342
SICI:
0910-5050(199812)89:12<1334:EOSSAG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; EXTRACELLULAR-MATRIX; PLASMINOGEN ACTIVATORS; URIDINE PHOSPHORYLASE; FACTOR-ALPHA; IN-VITRO; CANCER; METASTASIS; CARCINOMA; METALLOPROTEINASES;
Keywords:
ovarian adenocarcinoma; invasion; matrix metalloproteinase; thymidine phosphorylase; 5 '-deoxy-5-fluorouridine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ueda, M Osaka98686,oll, Dept Obstet & Gynecol, 2-7 Daigaku Cho, Takatsuki,Osaka 56 Osaka Med Coll 2-7 Daigaku Cho Takatsuki Osaka Japan 5698686 ka 56
Citazione:
M. Ueda et al., "Effects of sex steroids and growth factors on invasive activity and 5 '-deoxy-5-fluorouridine sensitivity in ovarian adenocarcinoma OMC-3 cells", JPN J CANC, 89(12), 1998, pp. 1334-1342

Abstract

Effects of sex steroids (estradiol-17 beta, E-2; progesterone, Frog) and growth factors (epidermal growth factor, EGF; transforming growth factor-a, TGF-a) on invasive activity and 5'-deoxy-5-fluorouridine (5'-dFUrd) sensitivity of ovarian adenocarcinoma OMC-3 cells were investigated. Tumor cell migration along a gradient of substratum-bound fibronectin and invasion into reconstituted basement membrane were inhibited by 10 mu M Frog, hut stimulated by 0.1-10 nM EGF and TGF-alpha in a concentration-dependent manner. E-2did not have any effect on tumor cell migration or invasion. The zymography of tumor conditioned medium showed that the treatment of OMC-3 cells withEGF and TGF-alpha resulted in increases of type IV collagenase, stromelysin and urokinase-type plasminogen activator (uPA). EGF and TGF-alpha up-regulated thymidine phosphorylase (dThdPase) expression of tumor cells and consequently enhanced the antiproliferative action of 5'-dFUrd, which is converted to 5-fluorouracil by dThdPase, E-2 and Prog did not have significant effects on the expression of proteolytic enzymes and dThdPase, or on the 5'-dFUrd sensitivity of tumor cells. The inhibitory effect of Frog on tumor cell invasion may depend on its inhibitory action on the motility of tumor cells. These results suggest that EGF and TGF-alpha simultaneously up-regulatethe potential of ovarian adenocarcinoma cells to invade extracellular matrices and their dThdPase expression, both of which are associated with the specific action of 5'-dFUrd selectively to kill tumor cells with high invasive and metastatic potential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:45:15