Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Protein tyrosine phosphorylation: A possible common signaling pathway in human Th1 and Th2 cell clones
Autore:
Minoguchi, K; Yamashita, N; Oda, N; Takeno, M; Kaneoka, H; Sakane, T;
Indirizzi:
St,Marianna Univ, Sch Med, Dept Immunol, Miyamae Ku, Kawasaki, Kanagawa 216 St Marianna Univ Kawasaki Kanagawa Japan 216 e Ku, Kawasaki, Kanagawa 216 Stpanrianna Univ, Sch Med, Dept Med, Miyamae Ku, Kawasaki, Kanagawa 216, Ja St Marianna Univ Kawasaki Kanagawa Japan 216 , Kawasaki, Kanagawa 216, Ja
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 1, volume: 118, anno: 1999,
pagine: 30 - 36
SICI:
1018-2438(199901)118:1<30:PTPAPC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; LYMPHOKINE PRODUCTION; IL-4 PRODUCTION; ZETA-CHAIN; ACTIVATION; KINASE; TRANSDUCTION; EXPRESSION; T-HELPER-1; PATTERNS;
Keywords:
Th1; Th2; tyrosine phosphorylation; ZAP-70;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sakane, T St,Marianna Univ, Sch Med, Dept Immunol, Miyamae Ku, 2-16-1 Sugao, Kawasaki St Marianna Univ 2-16-1 Sugao Kawasaki Kanagawa Japan 216 wasaki
Citazione:
K. Minoguchi et al., "Protein tyrosine phosphorylation: A possible common signaling pathway in human Th1 and Th2 cell clones", INT A AL IM, 118(1), 1999, pp. 30-36

Abstract

Background: It has been reported that protein tyrosine phosphorylation is essential for cytokine production in mouse Th1 cells but not in Th2 cells. However, little is known about the difference of signal transduction between human antigen-specific Th1 and Th2 cell clones. Methods: Purified proteinderivative-specific Th1 and Dermatophagoides farinae-specific Th2 cell clones were established. T cell clones were stimulated with anti-CD3 Abs and further treated with goat antimouse immunoglobulin Abs for cross-linking of TCR/CD3 complex. Results: In contrast to murine Th2 clones, tyrosine phosphorylation including both ZAP-70 and phospholipase-C-Al was necessary for cell activation in both types of human T cell clones. This was further supported by the observation that genistein (protein tyrosine kinase inhibitor) inhibits IFN-A production for Th1 and IL-4 for Th2 in a dose-dependent manner. Conclusion: Protein tyrosine phosphorylation is thus an essential component in transducing the activation signal from TCR-CD3 complex both in humanTh1 and Th2 cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:20:05