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Titolo:
Procalcitonin is not produced by circulating blood cells
Autore:
Monneret, G; Laroche, B; Bienvenu, J;
Indirizzi:
Ctr Hosp Lyon Sud, Immunol Lab, F-69495 Pierre Benite, France Ctr Hosp Lyon Sud Pierre Benite France F-69495 495 Pierre Benite, France
Titolo Testata:
INFECTION
fascicolo: 1, volume: 27, anno: 1999,
pagine: 34 - 35
SICI:
0300-8126(199901/02)27:1<34:PINPBC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Monneret, G Ctr Hosp Lyon Sud, Immunol Lab, F-69495 Pierre Benite, France Ctr Hosp Lyon Sud Pierre Benite France F-69495 enite, France
Citazione:
G. Monneret et al., "Procalcitonin is not produced by circulating blood cells", INFECTION, 27(1), 1999, pp. 34-35

Abstract

A large number of clinical studies has described procalcitonin (ProCT) as a marker of bacterial infection and a good predictor of disease severity and antibiotherapy efficacy. Nevertheless, the mechanism of ProCT synthesis remains unclear. The aim of this study was to demonstrate potential ProCT production by peripheral blood mononuclear cells as is the case for cytokinesinvolved in sepsis, In a whole blood model, LPS (10 mu g/ml) stimulation on blood samples from healthy volunteers (n = 14) was tested. Early (TNF-alpha and IL1-beta) and late (IL-6 and IL-8) cytokines were produced in large amounts in contrast to the absence of ProCT, Additional experiments with nitric oxide or detection of intra-cellular ProCT (cell lysis, flow cytometry) had negative results. It was concluded that ProCT is not produced in thismodel. Data are still needed to investigate the cellular origin of ProCT in order to better define its clinical usefulness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:26:36