Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells
Autore:
Ishiai, M; Kurosaki, M; Pappu, R; Okawa, K; Ronko, I; Fu, C; Shibata, M; Iwamatsu, A; Chan, AC; Kurosaki, T;
Indirizzi:
KansaiJapanUniv, Inst Liver Res, Dept Mol Genet, Moriguchi, Osaka 5708506,Kansai Med Univ Moriguchi Osaka Japan 5708506 , Moriguchi, Osaka 5708506, Washingtonunol,Divch Med, Howard Hughes Med Inst, Dept Internal Med,Ctr Imm Washington Univ St Louis MO USA 63110 Med Inst, Dept Internal Med,Ctr Imm Washington,Ctrv, Sch Med, Howard Hughes Med Inst, Dept Pathol,Div Rheumatol Washington Univ St Louis MO USA 63110 Med Inst, Dept Pathol,Div Rheumatol Kirinpanewery Co Ltd, Cent Labs Key Technol, Yokohama, Kanagawa 2360004, Ja Kirin Brewery Co Ltd Yokohama Kanagawa Japan 2360004 Kanagawa 2360004, Ja Ina Lab, Med Biol Labs, Nagano 3960002, Japan Ina Lab Nagano Japan 3960002 a Lab, Med Biol Labs, Nagano 3960002, Japan
Titolo Testata:
IMMUNITY
fascicolo: 1, volume: 10, anno: 1999,
pagine: 117 - 125
SICI:
1074-7613(199901)10:1<117:BRFCST>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; ANTIGEN RECEPTOR STIMULATION; PLECKSTRIN HOMOLOGY DOMAINS; PHOSPHOLIPASE C-GAMMA-2; PHOSPHATIDYLINOSITOL 3-KINASE; PROTOONCOGENE PRODUCT; DEPENDENT ACTIVATION; MOLECULAR-CLONING; DISTINCT PATHWAYS; LYMPHOCYTES-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Kurosaki, T KansaiJapanUniv, Inst Liver Res, Dept Mol Genet, Moriguchi, Osaka 5708506, Kansai Med Univ Moriguchi Osaka Japan 5708506 Osaka 5708506,
Citazione:
M. Ishiai et al., "BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells", IMMUNITY, 10(1), 1999, pp. 117-125

Abstract

Signaling through the B cell receptor (BCR) is essential for B cell function and development. Despite the key role of Syk in BCR signaling, little isknown about the mechanism by which Syk transmits downstream effecters. BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)gamma 2 and JNK. The BCR-induced PLC gamma S activation, but not the JNK activation, was restored by introductionof PLC gamma 2 membrane-associated form into BLNK-deficient B cells. As JNK activation requires both Rad and PLC gamma 2, our results suggest that BLNK regulates the Rac1-JNK pathway, in addition to modulating PLC gamma 2 localization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:12:30