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Titolo:
Effect of sinoaortic deafferentation on renal wrap hypertension
Autore:
VanNess, JM; Hinojosa-Laborde, C; Craig, T; Haywood, JR;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Pharmacol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 Pharmacol, San Antonio, TX 78284 USA Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 pt Physiol, San Antonio, TX 78284 USA
Titolo Testata:
HYPERTENSION
fascicolo: 1, volume: 33, anno: 1999,
parte:, 2 supplemento:, S
pagine: 476 - 481
SICI:
0194-911X(199901)33:1<476:EOSDOR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL-PRESSURE; BARORECEPTOR REFLEX; DENERVATED RATS; DOGS; NATRIURESIS; VOLUMES;
Keywords:
sympathetic activity; sinoaortic denervation; barodenervation; radiotelemetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Haywood, JR UTHSCSA Pharmacol, 7703 Floyd Curl Dr, San Antonio, TX 78284 USA UTHSCSA Pharmacol 7703 Floyd Curl Dr San Antonio TX USA 78284
Citazione:
J.M. VanNess et al., "Effect of sinoaortic deafferentation on renal wrap hypertension", HYPERTENSIO, 33(1), 1999, pp. 476-481

Abstract

The purpose of this study was to determine whether sinoaortic deafferentation (SAD) alters the severity of hypertension or sympathoadrenal contribution to mean blood pressure (MAP) during renal wrap hypertension. Male Sprague-Dawley rats were implanted with radiotelemetry transmitters for 24-hour recording of MAP and heart rate. All rats underwent either SAD or sham SAD (Intact) surgery and were allowed to recover for 10 to 14 days, The rats were then assigned to a normotensive (Sham) group or a hypertensive (Wrap) group in which 1-kidney figure-8 renal wrap was performed. SAD increased the acute MAP response to renal wrap (Intact-Sham=5+/-1 mmHg, Intact-Wrap=45+/-3mm Hg, SAD-Sham=3+/-3 mm Hg, SAD-Wrap=58+/-4 mm Hg) and increased the lability of MAP (SD of MAP; Intact-Sham=3.8+/-0.2, Intact-Wrap=4.2+/-0.3, SAD-Sham=9.6+/-1.4, SAD-Wrap=9.7+/-1.4), MAP was not different between SAD and Intact rats during 4 weeks after renal wrap or sham surgery; however, induction of hypertension produced additional MAP variability that was independent of SAD (Intact-Shaln=4.6+/-0.4, Intact-Wrap=6.2+/-0.6, SAD-Sham=6.3+/-0.5, SAD-Wrap=10.8+/-1.5). In a separate group of rats, the sympathoadrenal contribution to MAP was assessed by the depressor response to ganglionic blockade and plasma norepinephrine at rest and after neuronal uptake inhibitionwith desipramine, The depressor response to ganglionic blockade was significantly increased by renal wrap and by SAD (Intact-Sham=-49+/-2 mm Hg, Intact-Wrap=-73+/-4 mm Hg, SAD-Sham=-77+/-5 mm Hg, SAD-Wrap=-96+/-6 mm Hg). In the 3 groups with enhanced ganglionic blockade responses, desipramine caused a significant increase in plasma norepinephrine. These results indicate that SAD does not alter the development of renal wrap hypertension but does increase the sympathoadrenal contribution to MAP in both normotensive and hypertensive animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:03:27