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Titolo:
E-cadherin expression as a differentiation marker in gastric cancer
Autore:
Karayiannakis, AJ; Syrigos, KN; Chatzigianni, E; Papanikolaou, S; Karatzas, G;
Indirizzi:
1st IKA Hosp, Dept Surg 1, Athens, Greece 1st IKA Hosp Athens Greece1st IKA Hosp, Dept Surg 1, Athens, Greece St Bartholomews Hosp, Dept Med Oncol, London, England St Bartholomews Hosp London England sp, Dept Med Oncol, London, England 3rd IKA Hosp, Dept Pathol, Athens, Greece 3rd IKA Hosp Athens Greece3rd IKA Hosp, Dept Pathol, Athens, Greece Univ Athens, Sch Med, Propaedeut Dept Surg 2, GR-11527 Athens, Greece UnivAthens Athens Greece GR-11527 Dept Surg 2, GR-11527 Athens, Greece
Titolo Testata:
HEPATO-GASTROENTEROLOGY
fascicolo: 24, volume: 45, anno: 1998,
pagine: 2437 - 2442
SICI:
0172-6390(199811/12)45:24<2437:EEAADM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; HUMAN CARCINOMA-CELLS; BETA-CATENIN; IMMUNOHISTOCHEMICAL EVALUATION; GENE-MUTATIONS; ALPHA-CATENIN; APC; ADHESION; COMPLEX; PROTEIN;
Keywords:
cell adhesion; E-cadherin; gastric cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Karayiannakis, AJ 47 Peloponisou St, Athens 15341, Greece 47 Peloponisou St Athens Greece 15341 ns 15341, Greece
Citazione:
A.J. Karayiannakis et al., "E-cadherin expression as a differentiation marker in gastric cancer", HEP-GASTRO, 45(24), 1998, pp. 2437-2442

Abstract

BACKGROUND/AIMS: E-cadherin is a cell-cell adhesion molecule involved in tumor progression and metastasis. We evaluated the E-cadherin expression pattern in gastric cancer and investigated its relationship to histopathological features. METHODOLOGY: The expression of E-cadherin was evaluated in 83 formalin-fixed, paraffin-embedded specimens of gastric cancer by immunohistochemistry. RESULTS: In benign gastric mucosa, E-cadherin was expressed uniformly at the cell membrane. Abnormal E-cadherin expression with loss of membranous localization was found in 55 (56%) cancer specimens. Aberrant E-cadherin expression was found more often in diffuse (96%) and mixed type tumors (91%) than in intestinal type tumors (47%) (p = 0.0001). A significantly higher proportion of signet-ring (84%) and undifferentiated tumors (87%) showed abnormal E-cadherin expression compared with adenocarcinomas with glandular morphology (57%) (p = 0.01). There was a significant correlation between abnormal E-cadherin expression and degree of differentiation (p = 0.0001), local tumor extent (p = 0.002), and the presence of lymph node metastases (p = 0.04). CONCLUSIONS: Loss of normal E-cadherin expression may serve as a differentiation marker in gastric (sic).

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Documento generato il 27/10/20 alle ore 04:43:44