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Titolo: Multipletrait mapping of quantitative trait loci after selective genotyping using logistic regression
Autore: Henshall, JM; Goddard, ME;
 Indirizzi:
 Univ New England, Anim Genet & Breeding Unit, Armidale, NSW 2351, Australia Univ New England Armidale NSW Australia 2351 rmidale, NSW 2351, Australia
 Titolo Testata:
 GENETICS
fascicolo: 2,
volume: 151,
anno: 1999,
pagine: 885  894
 SICI:
 00166731(199902)151:2<885:MMOQTL>2.0.ZU;27
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 FLANKING MARKERS; LINKAGE; CROSSES; DESIGNS; YIELD;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Agriculture,Biology & Environmental Sciences
 Life Sciences
 Citazioni:
 23
 Recensione:
 Indirizzi per estratti:
 Indirizzo: Henshall, JM Univ New England, Anim Genet & Breeding Unit, Armidale, NSW 2351, Australia Univ New England Armidale NSW Australia 2351 2351, Australia



 Citazione:
 J.M. Henshall e M.E. Goddard, "Multipletrait mapping of quantitative trait loci after selective genotyping using logistic regression", GENETICS, 151(2), 1999, pp. 885894
Abstract
Experiments to map QTL usually measure several traits, and not uncommonly genotype only those animals that are extreme for some trait(s). Analysis ofselectively genotyped, multipletrait data presents special problems, and most simple methods lead to biased estimates of the QTL effects. The use oflogistic regression to estimate QTL effects is described, where the genotype is treated as the dependent variable and the phenotype as the independent variable. In this way selection on phenotype does not bias the results. If normally distributed errors are assumed, the logisticregression analyis is almost equivalent to a maximumlikelihood analysis, but can be carried out with standard statistical packages, Analysis of a simulated halfsib experiment shows that logistic regression can estimate the effect and positionof a QTL without bias and confirms the increased power achieved by multipletrait analysis.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 17:14:56