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Titolo:
Arylhydrocarbon receptor expression in the human endometrium
Autore:
Kuchenhoff, A; Seliger, G; Klonisch, T; Tscheudschilsuren, G; Kaltwasser, P; Seliger, E; Buchmann, J; Fischer, B;
Indirizzi:
Univ,Halle Wittenberg, Fac Med, Dept Anat & Cell Biol, D-06097 Halle, Saale Univ Halle Wittenberg Halle Saale Germany D-06097 l, D-06097 Halle, Saale Univale,le Wittenberg, Fac Med, Dept Obstet & Reprod Med, D-06097 Halle, Sa Univ Halle Wittenberg Halle Saale Germany D-06097 Med, D-06097 Halle, Sa Univ Halle Wittenberg, Fac Med, Dept Pathol, D-06097 Halle, Saale, GermanyUniv Halle Wittenberg Halle Saale Germany D-06097 7 Halle, Saale, Germany
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 2, volume: 71, anno: 1999,
pagine: 354 - 360
SICI:
0015-0282(199902)71:2<354:AREITH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARYL-HYDROCARBON RECEPTOR; AH-RECEPTOR; PREIMPLANTATION EMBRYOS; PROGESTERONE RECEPTORS; MENSTRUAL-CYCLE; ESTROGEN; TOXICITY; RAT; 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN; IDENTIFICATION;
Keywords:
arylhydrocarbon receptor; human; estrogen receptor; progesterone receptor; endometrium; menstrual cycle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kuchenhoff, A UnivD-06097Wittenberg, Fac Med, Dept Anat & Cell Biol, Grosse Steinstr 52, Univ Halle Wittenberg Grosse Steinstr 52 Halle Saale GermanyD-06097
Citazione:
A. Kuchenhoff et al., "Arylhydrocarbon receptor expression in the human endometrium", FERT STERIL, 71(2), 1999, pp. 354-360

Abstract

Objective: To determine the expression and localization of the arylhydrocarbon (dioxin) receptor in human endometrium throughout the normal menstrualcycle. Design: Retrospective immunohistochemical and in situ hybridization study. Setting: Academic research unit. Patient(s): Premenopausal women (n = 86), aged 25 to 45 years, with histologically normal endometrium undergoing curettage or hysterectomy. Intervention(s): Endometrial samples were collected from days 3 to 26 of the cycle by superficial scrapings of the uterine cavity or by hysterectomy. Main Outcome Measure(s): Expression of arylhydrocarbon receptor mRNA and protein. Result(s): Arylhydrocarbon receptor was expressed in 43% of the endometriastudied and was correlated with the day of the cycle. The maximum of immunopositive endometria was found around the time of ovulation. Immunostainingdecreased with increasing age of the patients. The receptor protein was localized exclusively in the apical part of the cytoplasm in the epithelial cells of the endometrial glands. In women positive for arylhydrocarbon receptor, arylhydrocarbon receptor mRNA war; expressed in the cytoplasm of endometrial epithelial cells. Conclusion(s): Our results describe the expression of the arylhydrocarbon receptor in human endometrium and indicate a possible involvement of this transcription factor in endometrial function in women during the reproductive phase. (Fertil Steril(R) 1999,71:354-60. (C) 1999 by American Society forReproductive Medicine.)

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 05:37:30