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Titolo:
Molecular genetic characterisation of intracerebrally transplanted brain tumours
Autore:
Schlegel, J; Piontek, G; Kuhne, C; Bartels, HJ; Kraus, A; Kappler, R; Mennel, HD;
Indirizzi:
Univ Marburg, Med Ctr, Dept Neuropathol, D-35043 Marburg, Germany Univ Marburg Marburg Germany D-35043 uropathol, D-35043 Marburg, Germany Univ Kaiserslautern, Dept Human Biol & Human Genet, Kaiserslautern, Germany Univ Kaiserslautern Kaiserslautern Germany net, Kaiserslautern, Germany
Titolo Testata:
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
fascicolo: 1, volume: 51, anno: 1999,
pagine: 41 - 45
SICI:
0940-2993(199901)51:1<41:MGCOIT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LINES; GLIOBLASTOMAS; TUMORS; MUTATIONS; MAJORITY; THERAPY; CANCER; FUTURE;
Keywords:
brain tumours; tumours brain; glioma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Schlegel, J Univmanyburg, Med Ctr, Dept Neuropathol, Baldingerstr, D-35043Marburg, Ger Univ Marburg Baldingerstr Marburg Germany D-35043 arburg, Ger
Citazione:
J. Schlegel et al., "Molecular genetic characterisation of intracerebrally transplanted brain tumours", EXP TOX PAT, 51(1), 1999, pp. 41-45

Abstract

The aim of the present study was the characterisation of genetic alterations in two different experimental gliomas, induced in rats from the inbred strain BDIX by transplacental ethylnitrosourea with subsequent serial transplantation. The genes investigated have been shown previously to be altered during human glial tumour progression and include the gene for the epidermal growth factor receptor (EGFR), the genes for the cell cycle regulators cyclin dependent kinase 4 (CDK4), cyclinD1 (cycD1), the p16 gene (MTS1/INK4) and the retinoblastoma gene (RB). Using a semi-quantitative PCR-based screening method no gross alterations could be detected in these genes, demonstrating that nitrosourea-induced glial rumours of rats do not harbour those genetic changes which typically arise in human malignant gliomas. Thus, the use of this tumour model for gene therapy trials is questionable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 16:59:40