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Titolo:
Sarcoplasmic lipase and non-specific esterase inhibition in myofibers of rats intoxicated with the organophosphate isofenphos
Autore:
Calore, EE; Sesso, A; Puga, FR; Cavaliere, MJ; Calore, NMP; Weg, R;
Indirizzi:
Emilio Ribas Inst, Sect Pathol, BR-01246902 Sao Paulo, Brazil Emilio RibasInst Sao Paulo Brazil BR-01246902 BC46902 Sao Paulo, Brazil Univ Sao Paulo, Fac Med, Lab Mol Pathol, Sao Paulo, Brazil Univ Sao PauloSao Paulo Brazil Med, Lab Mol Pathol, Sao Paulo, Brazil Inst Biol, Toxicol Sect, Sao Paulo, Brazil Inst Biol Sao Paulo BrazilInst Biol, Toxicol Sect, Sao Paulo, Brazil Adolfo Lutz Inst, Div Pathol, Sao Paulo, Brazil Adolfo Lutz Inst Sao Paulo Brazil z Inst, Div Pathol, Sao Paulo, Brazil
Titolo Testata:
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
fascicolo: 1, volume: 51, anno: 1999,
pagine: 27 - 33
SICI:
0940-2993(199901)51:1<27:SLANEI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOPATHY; PURIFICATION; MUSCLE; LIVER;
Keywords:
sarcoplasmic lipase; lipase, sarcoplasmic; organophosphate; isofenphos; myofibers, lipases, esterases, lipid-content; lipid content, myofibers; esterases, myofibers; muscle fibers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Calore, EE Emiliorazils Inst, Sect Pathol, Av Dr Arnaldo 165, BR-01246902 Sao Paulo, B Emilio Ribas Inst Av Dr Arnaldo 165 Sao Paulo Brazil BR-01246902 BC
Citazione:
E.E. Calore et al., "Sarcoplasmic lipase and non-specific esterase inhibition in myofibers of rats intoxicated with the organophosphate isofenphos", EXP TOX PAT, 51(1), 1999, pp. 27-33

Abstract

The expression of sarcoplasmic esterases, lipases as well as the lipid content in the myofibers of the diaphragm of rats intoxicated with the organophosphate isofenphos was studied. Lipid accumulation was documented at light, electron microsopic and by morphometric studies. The distribution of these lipid droplets was irregular and abundant in myofibers with numerous mitochondria (predominantly oxidative fibers). Histochemical inhibition of sarcoplasmic esterases and lipases was observed in the intoxicated animals. This sarcoplasmic inhibition of esterases occurs roughly in parallel to the inhibition of plasma cholinesterase activity. The inhibition of sarcoplasmic lipases may explain, at least partially, the accumulation of lipids. This inhibition probably makes difficult the use of lipids as fuel, especially inthe oxidative fibers. In contrast to the small amount of muscle necrosis, (1.30 +/- 0.745), metabolic muscle impairment was intense and extensive, i.e., decreased activities of esterases and lipases in the sarcoplasm, that should contribute to muscle weakness. Therefore, because segmental necrosis was most prominent in oxidative fibers (and these fibers use lipids as the principal fuel and contain the greater amount of lipases in the sarcoplasm), it is possible that inhibition of activity of lipases is responsible for the segmental necrosis. Although the exact role of these metabolic changes is not known, it is possible that they contribute not only to the inductionand evolution of muscle cell necrosis but also to the muscle weakness and clinical impairment of animals and humans in the acute intoxication by these compounds.

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Documento generato il 04/04/20 alle ore 15:30:28