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Titolo:
Spatiotemporal distribution of dying neurons during early mouse development
Autore:
van den Eijnde, SM; Lips, J; Boshart, L; Marani, E; Reutelingsperger, CPM; De Zeeuw, CI;
Indirizzi:
Erasmus Univ, Sch Med, Inst Plast Surg, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Erasmusdsniv, Sch Med, MGC Dept Clin Genet, NL-3000 DR Rotterdam, Netherlan Erasmus Univ Rotterdam Netherlands NL-3000 DR 00 DR Rotterdam, Netherlan Erasmus Univ, Sch Med, Dept Anat, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Univaastricht,t, Cardiovasc Res Inst Maastricht, Dept Biochem, NL-6229 ER M Univ Maastricht Maastricht Netherlands NL-6229 ER Biochem, NL-6229 ER M Leiden State Univ, Sch Med, Dept Physiol, NL-2300 RC Leiden, Netherlands Leiden State Univ Leiden Netherlands NL-2300 RC 0 RC Leiden, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 11, anno: 1999,
pagine: 712 - 724
SICI:
0953-816X(199902)11:2<712:SDODND>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; NERVE GROWTH-FACTOR; CHEMICALLY DEFINED MEDIUM; DORSAL-ROOT-GANGLIA; CEREBRAL-CORTEX; EMBRYONIC-DEVELOPMENT; SENSORY NEURONS; PLASMA-MEMBRANE; PHAGOCYTE RECOGNITION; APOPTOTIC CELLS;
Keywords:
apoptosis; cerebellum dorsal root ganglia; ganglion of the trigeminal nerve; optic nerve; pyknosis; Rathke's pouch; velum transversum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: van den Eijnde, SM Erasmusherlandsch Med, Inst Plast Surg, POB 1738, NL-3000 DR Rotterdam, Net Erasmus Univ POB 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
S.M. van den Eijnde et al., "Spatiotemporal distribution of dying neurons during early mouse development", EUR J NEURO, 11(2), 1999, pp. 712-724

Abstract

Apoptosis is a critical cellular event during several stages of neuronal development. Recently, we have shown that biotinylated annexin V detects apoptosis in vivo in various cell lineages of a wide range of species by binding to phosphatidylserines that are exposed at the outer leaflet of the plasma membrane. In the present study, we tested the specificity by which annexin V binds apoptotic neurons, and subsequently investigated developmental cell death in the central and peripheral nervous system of early mouse embryos at both the cellular and histological level, and compared the phagocyticclearance of apoptotic neurons with that of apoptotic mesodermal cells. Our data indicate: (i) that biotinylated annexin V can be used as a sensitivemarker that detects apoptotic neurons, including their extensions at an early stage during development; (ii) that apoptosis plays an important part during early morphogenesis of the central nervous system, and during early quantitative matching of brain-derived neurotrophic factor and neurotrophic factor 3 responsive postmitotic large clear neurons in the peripheral ganglia with their projection areas; and (iii) that apoptotic neurons are removed by a process that differs from classical phagocytosis of non-neuronal tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:06:31