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Titolo:
Effects of menopause on seizures in women with epilepsy
Autore:
Abbasi, F; Krumholz, A; Kittner, SJ; Langenberg, P;
Indirizzi:
Univ Maryland, Med Ctr, Dept Neurol, Sch Med, Baltimore, MD 21201 USA UnivMaryland Baltimore MD USA 21201 ol, Sch Med, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Maryland Epilepsy Ctr, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 pilepsy Ctr, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Dept Neurol, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Epidemiol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 t Epidemiol, Baltimore, MD 21201 USA
Titolo Testata:
EPILEPSIA
fascicolo: 2, volume: 40, anno: 1999,
pagine: 205 - 210
SICI:
0013-9580(199902)40:2<205:EOMOSI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGESTERONE;
Keywords:
menopause; epilepsy; seizures; women; hormones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Krumholz, A Univre,ryland, Med Ctr, Dept Neurol, Sch Med, N4W46,22 S Greene St, Baltimo Univ Maryland N4W46,22 S Greene St Baltimore MD USA 21201 timo
Citazione:
F. Abbasi et al., "Effects of menopause on seizures in women with epilepsy", EPILEPSIA, 40(2), 1999, pp. 205-210

Abstract

Purpose: Although important associations between epilepsy and women's hormonal phases are described, the relation of menopause to epilepsy has received little attention. Methods: By using a structured interview, we studied menopausal women withepilepsy seen at the University of Maryland Epilepsy Center over a 1-year period from 1994 to 1995. We analyzed the characteristics and temporal relation of the seizures to menopause and compared the frequency and severity of the seizures with those in a similar group of premenopausal women. Results: We identified 61 menopausal women (46 who were postmenopausal and15 perimenopausal) and compared them with 46 premenopausal women. No statistically significant differences were noted in either the frequency or the severity of seizures comparing all menopausal or only postmenopausal with premenopausal women. However, 12 (20%) of the 61 menopausal women noted thattheir seizures first began during or after menopause, with eight having noproven cause for their seizures. Many individual women described changes in their seizures with menopause. Among the 61 menopausal women, 49 had established epilepsy before the onset of menopause, and 20 (41%) reported worsening of their seizures with menopause, 13 (27%) noted improvement, and 16 (33%) described no changes. These observations were similar for peri- and postmenopausal women. Of the 15 menopausal women taking hormone replacement therapy, the six taking progestin were significantly less likely to report worsening of their seizures. Conclusions: These findings support the view that hormonal influences are important in women with seizures. Although, in aggregate, menopausal (combined perimenopausal and postmenopausal) and postmenopausal women's seizures were similar in frequency and severity to those of other women, menopause was associated with changes in seizures for some women. Moreover, menopause may be a previously unrecognized factor for some new-onset seizures. The relations between menopause and epilepsy deserve to be more fully investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:11:47