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Titolo:
Arterial compliance and distensibility are modulated by body composition in both men and women but by insulin sensitivity only in women
Autore:
Giltay, EJ; Lambert, J; Elbers, JMH; Gooren, LJG; Asscheman, H; Stehouwer, CDA;
Indirizzi:
Freendsiv Amsterdam Hosp, Dept Internal Med, NL-1007 MB Amsterdam, Netherla Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB rdam, Netherla Freedam,v Amsterdam Hosp, Inst Endocrinol Reprod & Metab, NL-1007 MB Amster Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB 1007 MB Amster Freelands Amsterdam Hosp, Cardiovasc Res Inst, NL-1007 MB Amsterdam, Nether Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB terdam, Nether
Titolo Testata:
DIABETOLOGIA
fascicolo: 2, volume: 42, anno: 1999,
pagine: 214 - 221
SICI:
0012-186X(199902)42:2<214:ACADAM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; LEFT-VENTRICULAR FAILURE; CAROTID-ARTERY; ESSENTIAL-HYPERTENSION; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; RISK-FACTORS; AORTIC DISTENSIBILITY; DIABETES-MELLITUS; SKELETAL-MUSCLE;
Keywords:
insulin sensitivity; carotid artery; femoral artery; distensibility coefficient; compliance coefficient; body composition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Stehouwer, CDA Free,Univ Amsterdam Hosp, Dept Internal Med, POB 7057, NL-1007 MB Amsterdam Free Univ Amsterdam Hosp POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
E.J. Giltay et al., "Arterial compliance and distensibility are modulated by body composition in both men and women but by insulin sensitivity only in women", DIABETOLOG, 42(2), 1999, pp. 214-221

Abstract

Large artery stiffening could contribute to the development of cardiovascular disease. The aim of this study was to investigate associations between arterial stiffness and diameter with insulin sensitivity and body composition in healthy men and women. In healthy, young (<41 years old), non-obese (BMI <27 kg/m(2)) men (n = 17) and women (n = 17), we measured the arterial diameter, the distension, the distensibility coefficient and the compliancecoefficient of the elastic common carotid and muscular femoral arteries with a non-invasive ultrasonographic method. We also assessed glucose uptake (by a euglycaemic hyperinsulinaemic clamp technique), total body fat and lean body mass (by bioelectrical impedance analysis) and abdominal subcutaneous and visceral fat area (by magnetic resonance imaging). In women, but notin men, the distension and distensibility and compliance coefficients of the femoral artery were negatively associated with insulin concentrations (beta = -0.62, p = 0.008; beta = -0.65, p = 0.005 and beta = -0.59, p = 0.01), and positively with glucose uptake (beta = 0.59, p = 0.02; beta = 0.68, p= 0.005 and beta = 0.54, p = 0.04). Associations with glucose uptake were independent of the mean arterial pressure and body composition. In men and women, arterial compliance was positively associated with fat mass variables, which were mediated by a strong association between the femoral artery diameter and lean body mass (beta = 0.80, p < 0.001) and between the common carotid artery diameter and visceral fat area (beta = 0.56, p = 0.001). We found an independent association between insulin resistance and arterial stiffness, which was more pronounced in women than in men.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 16:09:34