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Titolo:
Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages
Autore:
Boichot, E; Germain, N; Emonds-Alt, X; Advenier, C; Lagente, V;
Indirizzi:
Univ,Rennes 1, Fac Sci Pharmaceut & Biol, Lab Pharmacodynam & Pharmacol Mol Univ Rennes 1 Rennes France F-35043 l, Lab Pharmacodynam & Pharmacol Mol Univ Paris 05, Fac Med Paris Ouest, Lab Pharmacol Resp, Paris, France UnivParis 05 Paris France ris Ouest, Lab Pharmacol Resp, Paris, France Sanofi Rech, F-34082 Montpellier, France Sanofi Rech Montpellier France F-34082 Rech, F-34082 Montpellier, France
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 10, volume: 28, anno: 1998,
pagine: 1299 - 1305
SICI:
0954-7894(199810)28:10<1299:EOS1AS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AIRWAY HYPERRESPONSIVENESS; INDUCED BRONCHIAL HYPERRESPONSIVENESS; NK2 RECEPTOR ANTAGONIST; IN-VIVO; NONPEPTIDE ANTAGONIST; MICROVASCULAR LEAKAGE; TACHYKININ RECEPTORS; LUNG; NEUROPEPTIDES; INFILTRATION;
Keywords:
airway hyperresponsiveness; tachykinin receptor antagonists; guinea-pig; alveolar macrophage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Boichot, E Univ,Rennes 1, Fac Sci Pharmaceut & Biol, Lab Pharmacodynam & Pharmacol Mol Univ Rennes 1 2 Ave Pr Leon Bernard Rennes France F-35043 Mol
Citazione:
E. Boichot et al., "Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages", CLIN EXP AL, 28(10), 1998, pp. 1299-1305

Abstract

Background Tachykinins, such as substance P, might be involved in the development of airway hyperresponsiveness and airway inflammation. Objective This study was designed to investigate the effects of the tachykinin NK1 receptor antagonist SR 140333 (Nolpitantium) and the NK2 receptor antagonist SR 48968 (Saredutant) on the activation of alveolar macrophages in the guinea-pig. Methods Guinea-pigs sensitized and challenged by ovalbumin administered byaerosol or naive guinea-pigs were exposed by aerosol to the neutral endopeptidase, phosphoramidon and, 15 min later, to substance P. Twenty-four hours later, bronchoalveolar lavages were performed and the cell composition ofbronchoalveolar lavage fluids and the arachidonate release from alveolar macrophages stimulated in vitro with fMLP were evaluated. Results Antigen challenge in sensitized guinea-pigs induced an increase inthe total number of cells and granulocytes in the bronchoalveolar lavage fluids that was not reduced by pre-treatment of guinea-pigs with a single dose of SR 140333 or SR 48968 (1 mg/kg). Substance P exposure in phosphoramidon-pretreated guinea-pigs did not induce an increase in the total number ofcells. In contrast, antigen or substance P exposure induced a significant increase in the in vitro fMLP-induced arachidonate release from alveolar macrophages. Pre-treatment of the guinea pigs with SR 140333 or SR 48968 did not reduce the increase in arachidonate release from fMLP-stimulated alveolar macrophages from sensitized and challenged guinea-pigs. Pre-treatment ofthe animals by SR 140333 and SR 48968 reduced the enhanced arachidonate release induced by fMLP from substance P-exposed guinea-pigs. Conclusion The present data demonstrate the importance of NK1- and NK2-receptor stimulation in the development of substance P-induced increased reactivity of alveolar macrophages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 01:41:44