Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer
Autore:
Ambrosone, CB; Freudenheim, JL; Thompson, PA; Bowman, E; Vena, JE; Marshall, JR; Graham, S; Laughlin, R; Nemoto, T; Shields, PG;
Indirizzi:
Natl Ctr Toxicol Res, Div Mol Epidemiol, Jefferson, AR 72079 USA Natl Ctr Toxicol Res Jefferson AR USA 72079 miol, Jefferson, AR 72079 USA SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 al & Prevent Med, Buffalo, NY 14214 USA NCI, Human Carcinogenesis Lab, Bethesda, MD 20892 USA NCI Bethesda MD USA20892 uman Carcinogenesis Lab, Bethesda, MD 20892 USA Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 , Arizona Canc Ctr, Tucson, AZ 85724 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 3, volume: 59, anno: 1999,
pagine: 602 - 606
SICI:
0008-5472(19990201)59:3<602:MSD(GP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION; ALCOHOL-CONSUMPTION; UNITED-STATES; DNA-ADDUCTS; NEW-YORK; CELLS; OVEREXPRESSION; PHENOTYPE; DISEASES; SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Ambrosone, CB NatlUSAr Toxicol Res, Div Mol Epidemiol, 3900 NCTR Rd, Jefferson, AR 72079 Natl Ctr Toxicol Res 3900 NCTR Rd Jefferson AR USA 72079 079
Citazione:
C.B. Ambrosone et al., "Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer", CANCER RES, 59(3), 1999, pp. 602-606

Abstract

Oxidative stress, resulting from the imbalance between prooxidant and antioxidant states, damages DNA, proteins, cell membranes, and mitochondria andseems to play a role in human breast carcinogenesis. Dietary sources of antioxidants (chemical) and endogenous antioxidants (enzymatic), including the polymorphic manganese superoxide dismutase (MnSOD), can act to reduce theload of oxidative stress. We hypothesized that the valine-to-alanine substitution that seems to alter transport of the enzyme into the mitochondrion.changing its efficacy in fighting oxidative stress, was associated with breast cancer risk and that a diet rich in sources of antioxidants could ameliorate the effects on risk. Data were collected in a case-control study of diet and breast cancer in western New York from 1986 to 1991. Caucasian women with incident, primary, histologically confirmed breast cancer were frequency-matched on age and county of residence to community controls. Blood specimens were collected and processed from a subset of participants in the study (266 cases and 295 controls). Using a RFLP that distinguishes a valine (V) to alanine (A) change in the -9 position in the signal sequence of the protein for MnSOD, we characterized MnSOD genotypes in relation to breastcancer risk, We also evaluated the effect of the polymorphism on risk among low and high consumers of Fruits and vegetables. Premenopausal women who were homozygous for the A allele had a 4-fold increase in breast cancer risk in comparison to those with 1 or 2 V alleles (odds ratio, 4.3; 95% confidence interval, 1.7-10.8). Risk was most pronounced among women below the median consumption of fruits and vegetables and of dietary ascorbic acid and cu-tocopherol, with little increased risk for those with diets rich in these foods, Relationships were weaker among postmenopausal women, although theMnSOD AA genotype was associated with an almost 2-fold increase in risk (odds ratio, 1.8; confidence interval, 0.9-3.6), No appreciable modification of risk by diet was detected for these older women. These data support the hypothesis that MnSOD and oxidative stress play a significant role in breast cancer risk, particularly in premenopausal women, The finding that risk was greatest among women who consumed lo rc er amounts of dietary antioxidants and was minimal among high consumers indicates that a diet rich in sources of antioxidants may minimize the deleterious effects of the MnSOD polymorphism, thereby supporting public health recommendations for the consumption of diets rich in fruits and vegetables as a preventive measure against cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 08:49:02