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Titolo:
Elevated serum levels of transforming growth factor-beta 1 in patients with colorectal carcinoma - Its association with tumor progression and its significant decrease after curative surgical resection
Autore:
Shim, KS; Kim, KH; Han, WS; Park, EB;
Indirizzi:
Ewhaoreaans Univ, Coll Med, Ewha Med Res Ctr, Dept Gen Surg, Seoul, South K Ewha Womans Univ Seoul South Korea s Ctr, Dept Gen Surg, Seoul, South K Ewha Womans Univ, Coll Med, Dept Pathol, Seoul, South Korea Ewha Womans Univ Seoul South Korea Med, Dept Pathol, Seoul, South Korea
Titolo Testata:
CANCER
fascicolo: 3, volume: 85, anno: 1999,
pagine: 554 - 561
SICI:
0008-543X(19990201)85:3<554:ESLOTG>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-COLON-CARCINOMA; FACTOR-BETA ISOFORMS; HUMAN BREAST-CANCER; CARCINOEMBRYONIC ANTIGEN; HEPATOCELLULAR-CARCINOMA; DISEASE PROGRESSION; TGF-BETA; GROWTH-FACTOR-BETA-1 LEVEL; PULMONARY ADENOCARCINOMA; PROGNOSTIC-SIGNIFICANCE;
Keywords:
transforming growth factor (TGF)-beta 1; colorectal carcinoma; biomarker; enzyme-linked immunoadsorbent assay (ELISA); serum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Shim, KS Ewhareamans Univ, Mokdong Hosp, 911-1 Mokdong,Yangcheon Ku, Seoul, South Ko Ewha Womans Univ 911-1 Mokdong,Yangcheon Ku Seoul South Korea o
Citazione:
K.S. Shim et al., "Elevated serum levels of transforming growth factor-beta 1 in patients with colorectal carcinoma - Its association with tumor progression and its significant decrease after curative surgical resection", CANCER, 85(3), 1999, pp. 554-561

Abstract

BACKGROUND. Transforming growth factor-beta 1 (TGF-beta 1) acts as a potent inhibitor of cell growth and turner progression but loss of this negativeregulation can contribute to tumor development. Some studies have reportedan association between disease progression and TGF-beta 1 expression in patients with colorectal carcinoma, but their results were not always consistent. METHODS. Serum levels of TGF-beta 1 were measured using an enzyme-linked immunoadsorbent assay in 121 consecutive patients with colorectal carcinoma and compared with TGF-beta 1 serum levels in 31 healthy volunteers. Serum levels of TGF-beta 1 also were measured in 50 patients who underwent curative surgical resection (part of the 121 preoperative patients) to compare their levels with preoperative serum levels of TGF-beta 1. RESULTS, Serum levels of TGF-beta 1 in patients with colorectal carcinoma (45 +/- 15 ng/mL) (mean +/- the standard deviation) were significantly higher than those in the healthy control group (32 +/- 4 ng/mL) (P = 0.001). Serum levels of TGF-beta 1 increased with increasing tumor stage (P < 0.01). Serum Levels of TGF-beta 1 were correlated significantly with depth of turner invasion, lymph node metastasis, distant metastasis, and serum levels ofcarcinoembryonic antigen (CEA). Serum levels of TGF-beta 1 tended to increase with increasing CEA (correlation coefficient = 0.21; P < 0.05). The mean serum level of TGF-beta 1 in patients with colorectal carcinoma before surgery (45 +/- 14 ng/mL) (n = 50) significantly decreased to 34 +/- 7 ng/mL,which was within the normal range (32 +/- 4 ng/mL), after curative surgical resection of the tumor (P = 0.0000). Serum levels of TGF-beta 1 after tumor resection decreased more significantly in patients with higher preoperative levels of TGF-PI (from 53 +/- 12 ng/mL to 36 +/- 6 ng/mL) (n = 30). CONCLUSIONS. The results of the current study suggest that serum levels ofTGF-beta 1 in colorectal carcinoma patients may be associated with diseaseprogression and may be used as a biomarker in the management of colorectalcarcinoma patients. The authors believe further studies with a large number of patients for a longer follow-up period are necessary to conclude whether serum levels of TGF-beta 1 carry significant clinical relevance. [See editorial on pages 517-9, this issue]. Cancer 1999;85:554-61, (C) 1999 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 09:03:38