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Titolo:
Age-dependent alteration of metabolic response to photic stimulation in the human brain measured by P-31 MR-spectroscopy
Autore:
Murashita, J; Kato, T; Shioiri, T; Inubushi, T; Kato, N;
Indirizzi:
Univ Tokyo, Fac Med, Dept Neuropsychiat, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Dept Neuropsychiat, Tokyo 1138655, Japan Shiga Univ Med Sci, Dept Psychiat, Shiga 5202121, Japan Shiga Univ Med Sci Shiga Japan 5202121 pt Psychiat, Shiga 5202121, Japan Shiga Univ Med Sci, Mol Neurobiol Res Ctr, Shiga 5202121, Japan Shiga UnivMed Sci Shiga Japan 5202121 iol Res Ctr, Shiga 5202121, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 818, anno: 1999,
pagine: 72 - 76
SICI:
0006-8993(19990206)818:1<72:AAOMRT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; MUSCLE METABOLISM; VISUAL-CORTEX; IN-VIVO; REDUCTION; DISORDER; LACTATE; OXYGEN; YOUNG; H-1;
Keywords:
phosphorus-31 magnetic resonance spectroscopy; brain energy metabolism; creatine phosphate; intracellular pH; membrane phospholipid; photic stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, T Univ Tokyo, Fac Med, Dept Neuropsychiat, Hongo 7-3-1, Tokyo 1138655, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1138655 , Tokyo 1138655, Japan
Citazione:
J. Murashita et al., "Age-dependent alteration of metabolic response to photic stimulation in the human brain measured by P-31 MR-spectroscopy", BRAIN RES, 818(1), 1999, pp. 72-76

Abstract

Effects of photic stimulation (PS) on energy metabolism were examined in the occipital cortex of 25 healthy volunteers aged 23-69 years old using phosphorus-31 magnetic resonance spectroscopy (P-31-MRS). A significant effectof photic stimulation was found only for intracellular pH (p < 0.05 by repeated measures analysis of variance) but not for any peak area ratios, An interaction between intracellular pH and age were statistically significant (p < 0.005), and the interaction between phosphocreatine and age was close to significance (p =0.06). In subjects aged more than 40 years old, phosphocreatine was significantly decreased during the photic stimulation (p < 0.05, multiple comparison by Dunnett's method), and intracellular pH tended tobe elevated just after the stimulation (p = 0.07). There were no significant changes in these values in younger subjects. These results suggest that no significant effect of photic stimulation on brain energy metabolism was found in younger subjects, and that significant effects of photic stimulation on intracellular pH and phosphocreatine were found in middle-aged subjects. Metabolic response of the human brain to photic stimulation may be dependent on age. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 17/01/20 alle ore 20:08:47