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Titolo:
Platelet adhesion and complement activation studies on poly(N-alkyl mono and disubstituted) acrylamide derivatives
Autore:
Bahulekar, R; Tamura, N; Ito, S; Kodama, M;
Indirizzi:
Natl5,nst Adv Interdisciplinary Res, Bion Design Res Grp, Ibaraki, Osaka 30 Natl Inst Adv Interdisciplinary Res Ibaraki Osaka Japan 305 aki, Osaka 30 Univ Tsukuba, Inst Basic Med Sci, Ibaraki, Osaka 305, Japan Univ Tsukuba Ibaraki Osaka Japan 305 c Med Sci, Ibaraki, Osaka 305, Japan
Titolo Testata:
BIOMATERIALS
fascicolo: 4, volume: 20, anno: 1999,
pagine: 357 - 362
SICI:
0142-9612(199902)20:4<357:PAACAS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD COMPATIBLE POLYMERS; COPOLYMERS;
Keywords:
poly(N-alkyl substituted) acrylamides; platelet adhesion; complement activation; antithrombogenicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Kodama, M Natlaraki,Adv Interdisciplinary Res, Bion Design Res Grp, 1-1-4 Higashi, Ib Natl Inst Adv Interdisciplinary Res 1-1-4 Higashi Ibaraki OsakaJapan 305
Citazione:
R. Bahulekar et al., "Platelet adhesion and complement activation studies on poly(N-alkyl mono and disubstituted) acrylamide derivatives", BIOMATERIAL, 20(4), 1999, pp. 357-362

Abstract

Poly(N-alkyl mono and disubstituted) acrylamide derivatives were synthesized from poly(acryloyl chloride) by monomer analogous reaction. The polymerswere characterized by FTIR-ATR and GPC. The contact angle measurements were performed to evaluate hydrophobic/hydrophilic characters of these polymers. The N-alkyl substituents changed contact angle between 55 and 75 degrees. In vitro platelet adhesion studies showed that surfaces of poly(N-alkyl substituted) acrylamides are prone to adhere platelets. Platelet spreading was more on poly(N-benzyl-N-ethyl acrylamide) surfaces in comparison to thaton poly(N-benzyl-N-propionic acid ethyl eater acrylamide) and poly(hi-benzyl acrylamide) surfaces. As a result of modification of amino group with N-alkyl substituents, the activations of C3a and C5a complements were suppressed 9-20% and 5-6% of native poly(acrylamides), respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:31:19