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Titolo:
Associations of anti-beta(2)-glycoprotein I autoantibodies with HLA class II alleles in three ethnic groups
Autore:
Arnett, FC; Thiagarajan, P; Ahn, C; Reveille, JD;
Indirizzi:
Univ Texas, Sch Med, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 niv Texas, Sch Med, Houston, TX 77030 USA
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 2, volume: 42, anno: 1999,
pagine: 268 - 274
SICI:
0004-3591(199902)42:2<268:AOAIAW>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; PRIMARY ANTIPHOSPHOLIPID SYNDROME; ANTICARDIOLIPIN ANTIBODIES; CLINICAL MANIFESTATIONS; MEXICAN PATIENTS; ANTICOAGULANT; BETA(2)-GLYCOPROTEIN-I; THROMBOSIS; DISEASES; CRITERIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Arnett, FC Univ Texas, Sch Med, 6431 Fannin, Houston, TX 77030 USA Univ Texas 6431 Fannin Houston TX USA 77030 uston, TX 77030 USA
Citazione:
F.C. Arnett et al., "Associations of anti-beta(2)-glycoprotein I autoantibodies with HLA class II alleles in three ethnic groups", ARTH RHEUM, 42(2), 1999, pp. 268-274

Abstract

Objective. To determine any HLA associations with anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibodies in a large, retrospectively studied, multiethnic group of 262 patients with primary antiphospholipid antibody syndrome (APS), systemic lupus erythematosus (SLE), or another connective tissue disease. Methods. Anti-beta(2)GPI antibodies were detected in sera using an enzyme-linked immunosorbent assay. HLA class II alleles (DRB1, DQA1, and DQB1) were determined by DNA oligotyping. Results. The HLA-DQB1*0302 (DQ8) allele, typically carried on HLA-DR4 haplotypes, was associated with anti-beta(2)GPI when compared with both anti-beta(2)GPI-negative SLE patients and ethnically matched normal controls, especially in Mexican Americans and, to a lesser extent, in whites. Similarly, when ethnic groups were combined, HLA-DQB1*0302, as well as HLA-DQB1*03 alleles overall (DQB1*0301, *0302, and *0303), were strongly correlated with anti-beta(2)GPI antibodies. The HLA-DR6 (DR13) haplotype DRB1*1302; DQB1*0604/5 was also significantly increased, primarily in blacks. HLA-DR7 was not significantly increased in any of these 3 ethnic groups, and HLA-DR53 (DRB4*0101) was increased in Mexican Americans only. Conclusion. Certain HLA class II haplotypes genetically influence the expression of antibodies to beta(2)GPI, an important autoimmune response in theAPS, but there are variations in HLA associations among different ethnic groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 10:52:49