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Titolo:
Endothelin and endothelin receptors A and B in the human testis
Autore:
Ergun, S; Harneit, S; Paust, HJ; Mukhopadhyay, AK; Holstein, AF;
Indirizzi:
UKE, Inst Anat, D-20246 Hamburg, Germany UKE Hamburg Germany D-20246UKE, Inst Anat, D-20246 Hamburg, Germany Univ Hamburg, Inst Hormone & Fertil Res, Hamburg, Germany Univ Hamburg Hamburg Germany nst Hormone & Fertil Res, Hamburg, Germany
Titolo Testata:
ANATOMY AND EMBRYOLOGY
fascicolo: 3, volume: 199, anno: 1999,
pagine: 207 - 214
SICI:
0340-2061(199903)199:3<207:EAERAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; LEYDIG-CELLS; VASOCONSTRICTOR PEPTIDE; HORSERADISH-PEROXIDASE; SEMINIFEROUS TUBULES; BINDING-SITES; CDNA; LOCALIZATION; CLONING; IMMUNOREACTIVITY;
Keywords:
blood vessels; Leydig cells; Sertoli cells; peritubular cells; microcirculation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ergun, S UKE, Inst Anat, Martinistr 52, D-20246 Hamburg, Germany UKE Martinistr 52 Hamburg Germany D-20246 20246 Hamburg, Germany
Citazione:
S. Ergun et al., "Endothelin and endothelin receptors A and B in the human testis", ANAT EMBRYO, 199(3), 1999, pp. 207-214

Abstract

Human testicular capillaries interconnect Leydig cells and seminiferous tubules. Microcirculation and blood flow are therefore essential for the maintenance of spermatogenesis. The expression and the localisation of ET (endothelin) and its receptors in testicular tissue, in seminiferous tubules andin human testicular capillaries were studied. ET-1 mRNA was detected in whole testicular tissue and in seminiferous tubules whereas isolated testicular capillaries were negative. Big ET-1 (Big endothelin 1) and ET peptides were localised in Leydig and Sertoli cells whereas interstitial and intramural capillaries (within the lamina propria) remained unstained. ET was also found in mature spermatids. ET-A (endothelin receptor A) mRNA was detected in seminiferous tubules and whole testicular tissue whereas testicular blood vessels were negative. ET-A immunostaining was displayed in Leydig and Sertoli cells and in spermatids. ET-B (endothelin receptor B) mRNA was detected in whole testicular tissue, seminiferous tubules and in testicular capillaries. ET-B peptide was prominent in Leydig cells, peritubular cells, endothelial cells and pericytes of interstitial and intramural capillaries as well as in vascular endothelial and smooth muscle cells. From these results we conclude that ET produced in Leydig and Sertoli cells can act in a paracrine manner via ET-B on the human testicular microvasculature and the peritubular cells. The presence of both ET-A and ET-B in Leydig cells and of ET-A in Sertoli cells leads to the assumption that ET could influence these cells as an autocrine factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:39:52