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Titolo:
Body weight and leptin plasma levels during treatment with antipsychotic drugs
Autore:
Kraus, T; Haack, M; Schuld, A; Hinze-Selch, D; Kuhn, M; Uhr, M; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 2, volume: 156, anno: 1999,
pagine: 312 - 314
SICI:
0002-953X(199902)156:2<312:BWALPL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE; CLOZAPINE; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
T. Kraus et al., "Body weight and leptin plasma levels during treatment with antipsychotic drugs", AM J PSYCHI, 156(2), 1999, pp. 312-314

Abstract

Objective: Leptin is produced by fat cells and is presumed to signal the size of the adipose tissue to the brain. The authors investigated whether antipsychotic drugs that often induce weight gain affect circulating levels of leptin. Method: Weight, body mass index, and leptin plasma level were measured weekly over 4 weeks in psychiatric inpatients who received clozapine (N=11), olanzapine (N=8), haloperidol (N=13), or no psychopharmacological treatment (N=12). Results: In patients receiving clozapine or olanzapine, significant increases in weight, body mass index, and leptin level were found, whereas these measures remained stable in patients who received haloperidol or no pharmacological treatment. Conclusions: Weight gain induced by clozapine or olanzapine appears to be associated with an increase in leptin level that cannot be attributed to dietary changes upon hospitalization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:57:17