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Titolo:
Diazepam treatment of early signs of exacerbation in schizophrenia
Autore:
Carpenter, WT; Buchanan, RW; Kirkpatrick, B; Breier, AF;
Indirizzi:
Univ8Maryland, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 2122 Univ Maryland Baltimore MD USA 21228 Psychiat Res Ctr, Baltimore, MD 2122 Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA Lilly Corp CtrIndianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 2, volume: 156, anno: 1999,
pagine: 299 - 303
SICI:
0002-953X(199902)156:2<299:DTOESO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATMENT-RESISTANT SCHIZOPHRENIA; PRODROMAL SYMPTOMS; NEGATIVE SYMPTOMS; RELAPSE; TRIAL; GLYCINE; THERAPY; NEUROLEPTICS; MEDICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Carpenter, WT Univre,ryland, Dept Psychiat, Maryland Psychiat Res Ctr, POB21247, Baltimo Univ Maryland POB 21247 Baltimore MD USA 21228 1247, Baltimo
Citazione:
W.T. Carpenter et al., "Diazepam treatment of early signs of exacerbation in schizophrenia", AM J PSYCHI, 156(2), 1999, pp. 299-303

Abstract

Objective: Therapeutic intervention at the earliest phase of symptom exacerbation in schizophrenia is an important clinical need, but specific pharmacotherapeutic interventions for this phase of illness have not been established. This study examined diazepam efficacy for this phase of treatment. Method: A double-blind, randomized clinical trial with 53 schizophrenic patients compared diazepam with placebo (with fluphenazine treatment for a comparison group). Treatment was initiated at the earliest signs of exacerbation, and symptom progression was the dependent measure used to evaluate efficacy. Results: Diazepam was statistically superior to placebo in preventing symptom progression and was comparable to fluphenazine. Conclusions: Efficacy data support the use of diazepam in treating prodromal and early warning signs of symptom exacerbation in schizophrenia. This therapeutic strategy may be especially important for patients who refuse antipsychotic drugs or as a supplemental approach in a treatment plan that emphasizes low-dose antipsychotic therapy.

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Documento generato il 18/09/20 alle ore 16:14:00