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Titolo:
Effect of endurance exercise on myosin heavy chain gene regulation in human skeletal muscle
Autore:
ONeill, DS; Zheng, DH; Anderson, WK; Dohm, GL; Houmard, JA;
Indirizzi:
E Carolina Univ, Sch Med, Dept Exercise & Sport Sci, Human Performance Lab, E Carolina Univ Greenville NC USA 27858 Sport Sci, Human Performance Lab, E Carolina Univ, Sch Med, Dept Biochem, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 Biochem, Greenville, NC 27858 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 2, volume: 45, anno: 1999,
pagine: R414 - R419
SICI:
0363-6119(199902)45:2<R414:EOEEOM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; EXPRESSION; ISOFORMS; PROTEIN; FIBERS; STIMULATION; INCREASE; MEN;
Keywords:
contractile activity; muscle fiber type;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Houmard, JA E Carolina Univ, Sch Med, Dept Exercise & Sport Sci, Human Performance Lab, E Carolina Univ Ward Sports Med Bldg Greenville NC USA 27858 ,
Citazione:
D.S. O'Neill et al., "Effect of endurance exercise on myosin heavy chain gene regulation in human skeletal muscle", AM J P-REG, 45(2), 1999, pp. R414-R419

Abstract

The purpose of this study was to determine the effect of endurance-oriented exercise on myosin heavy chain (MHC) isoform regulation in human skeletalmuscle. Exercise consisted of 1 h of cycle ergometer work per day at 75% maximal oxygen consumption for seven consecutive days. Muscle was obtained before the first bout of exercise, 3 h after the first bout of exercise, andbefore and 3 h after the final exercise bout on day 7 (n = 9 subjects). Nochanges in MHC mRNA (I, IIa, IIx) were evident after the first exercise period. There was, however, a significant (P < 0.05) decline (-30%) in MHC IIx mRNA 3 h after the final training bout. An interesting finding was that ahigher pretraining level of MHC IIx mRNA was associated with a greater decline in the transcript before (r = 0.68, P < 0.05) and 3 h after (r = 0.82,P < 0.05) the final exercise bout. These findings suggest that MHC IH mRNAis downregulated during the early phase of endurance-oriented exercise training in human skeletal muscle but only after repeated contractile activity. Pretraining MHC IIx mRNA content may influence the magnitude of this response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 04:27:18