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Titolo:
Population substructure and isolation by distance in three continental regions
Autore:
Eller, E;
Indirizzi:
Univ Utah, Dept Anthropol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 ropol, Salt Lake City, UT 84112 USA Penn State Univ, Dept Anthropol, University Pk, PA 16801 USA Penn State Univ University Pk PA USA 16801 l, University Pk, PA 16801 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
fascicolo: 2, volume: 108, anno: 1999,
pagine: 147 - 159
SICI:
0002-9483(199902)108:2<147:PSAIBD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-EVOLUTION; GENETICS; POLYMORPHISMS; DIVERSITY; ORIGINS; MATRIX;
Keywords:
short tandem repeats (STRs); principal components analysis (PCA); Mantel test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Eller, E Univ Utah, Dept Anthropol, 102 Stewart Bldg, Salt Lake City, UT 84112 USA Univ Utah 102 Stewart Bldg Salt Lake City UT USA 84112 84112 USA
Citazione:
E. Eller, "Population substructure and isolation by distance in three continental regions", AM J P ANTH, 108(2), 1999, pp. 147-159

Abstract

Isolation by distance and divergence from a shared population history are two sources of population substructure. Isolation by distance erases population history as populations approach migration-drift equilibrium, while diverging populations descended from a single ancestral population will accumulate genetic differences with time. Here I investigate how much of the worldwide genetic diversity from Jorde et al.'s ([1997] Proc. Natl. Acad. Sci. USA 94:3100-3103) 60 tetranucleotide short tandem repeat (STR) data can be explained by isolation by distance. I use Slatkin's measure of population substructure, R-ST principal components analyses, and Mantel tests to investigate the pattern of genetic diversity at both the intercontinental and intracontinental levels. Geographic distance accounts for almost 60% of worldwide interpopulation genetic relationships. Within continents, the correlations are less, although not significantly so because of wide confidence intervals. These results suggest that populations have not reached migration-drift equilibrium and that there is information in STR data to reconstruct population history. The level of population substructure worldwide is consistent with previousobservations, but at the intracontinental level substructure is less. Whenone examines diversity against distance from the centroid, one sees excessheterozygosity in Africa, a pattern also noted by Stoneking et al. ([1998]Genome Research 7:1061-1071). A larger effective population size in Africacould explain the excess diversity. Greater gene flow in Africa is an unlikely explanation because the African R-ST value is slightly larger than theAsian and European R(ST)s, pointing to less gene flow and greater substructure among African populations. Furthermore, there are differences in patterns between heterozygosity and allele size variance. Heterozygosity has a higher correlation with distance from the centroid than does allele size variance, and this may reflect demographic history. Kimmel et al. ([1998] Genetics 148:1921-1930) have shown that after a population expansion heterozygosity returns to equilibrium more quickly than does allele size variance. The contrasting patterns between heterozygosity and allele size variance may reflect different times after an expansion. However, simulations and further work need to be done to more thoroughly investigate the possibility that these data reflect population expansions. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 02/12/20 alle ore 18:05:31