Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Characteristic MR lesion pattern and correlation of T1 and T2 lesion volume with neurologic and neuropsychological findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
Autore:
Yousry, TA; Seelos, K; Mayer, M; Bruning, R; Uttner, I; Dichgans, M; Mammi, S; Straube, A; Mai, N; Filippi, M;
Indirizzi:
UnivyMunich, Klinikum Grosshadern, Dept Neuroradiol, D-81377 Munich, German Univ Munich Munich Germany D-81377 t Neuroradiol, D-81377 Munich, German Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 Dept Neurol, D-81377 Munich, Germany Univrmanych, Klinikum Grosshadern, Dept Diagnost Radiol, D-81377 Munich, Ge Univ Munich Munich Germany D-81377 t Diagnost Radiol, D-81377 Munich, Ge Univ Milan, Osped San Raffaele, Inst Sci, Dept Neurol, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 st Sci, Dept Neurol, I-20122 Milan, Italy
Titolo Testata:
AMERICAN JOURNAL OF NEURORADIOLOGY
fascicolo: 1, volume: 20, anno: 1999,
pagine: 91 - 100
SICI:
0195-6108(199901)20:1<91:CMLPAC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL HEMIPLEGIC MIGRAINE; MULTIPLE-SCLEROSIS LESIONS; SPIN-ECHO IMAGES; DEMENTIA; DISEASE; STROKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Yousry, TA Univ1377ich, Klinikum Grosshadern, Dept Neuroradiol, Marchioninistr 15, D-8 Univ Munich Marchioninistr 15 Munich Germany D-81377 r 15, D-8
Citazione:
T.A. Yousry et al., "Characteristic MR lesion pattern and correlation of T1 and T2 lesion volume with neurologic and neuropsychological findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)", AM J NEUROR, 20(1), 1999, pp. 91-100

Abstract

BACKGROUND AND PURPOSE: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an arteriopathy related to a genetic defect of the notch 3 gene on chromosome 19. The purpose ofthis study was to evaluate lesion distribution and volume using MR imagingand to correlate the lesion volume with the neurologic and neuropsychological findings. METHODS: Twenty members of two families (14 with CADASIL as determined by linkage analysis, six healthy) were studied with MR imaging. Two observers evaluated the MR findings semiquantitatively and quantitatively. MR resultswere then correlated with neurologic and neuropsychological findings. RESULTS: A typical pattern of lesion distribution in patients with CADASILwas found: the frontal lobe was the site with the highest lesion load, followed by the temporal lobe and the insula. The total lesion volume on T1-weighted MR images correlated significantly with the degree of disability andthe degree of impairment in neuropsychological functions (including attention, memory, and conceptual and visuospatial functions). CONCLUSION: In CADASIL patients, a common pattern of cerebral lesion distribution is found. The total T1 lesion volume is an important parameter to correlate with disability, as it may prove to be helpful in predicting the natural history of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:40:55