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Titolo:
EFFECT OF UNILATERAL NEPHRECTOMY ON GENE-EXPRESSION OF METALLOPROTEINASES AND THEIR INHIBITORS
Autore:
KOIDE H; NAKAMURA T; EBIHARA I; TOMINO Y;
Indirizzi:
KOTO HOSP,DEPT MED,DIV NEPHROL,KOTO KU,6-8-5 OJIMA TOKYO 136 JAPAN JUNTENDO UNIV,SCH MED TOKYO 113 JAPAN
Titolo Testata:
Nephron
fascicolo: 4, volume: 75, anno: 1997,
pagine: 479 - 483
SICI:
0028-2766(1997)75:4<479:EOUNOG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; RENAL HYPERTROPHY; IV COLLAGENASE; AMINONUCLEOSIDE NEPHROSIS; DIABETIC RATS; C-FOS; GLOMERULI; GLOMERULOSCLEROSIS; CELLS; HYPERPLASIA;
Keywords:
COMPENSATORY RENAL GROWTH; EXTRACELLULAR MATRIX; CELLULAR HYPERTROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
H. Koide et al., "EFFECT OF UNILATERAL NEPHRECTOMY ON GENE-EXPRESSION OF METALLOPROTEINASES AND THEIR INHIBITORS", Nephron, 75(4), 1997, pp. 479-483

Abstract

Levels of mRNA encoding for metalloproteinase (MMP) 1, 2, 3 and 9 andtissue inhibitor of metalloproteinase (TIMP) 1 were measured in both the renal cortex and glomeruli following unilateral nephrectomy or a sham operation. The expression of MMP-1 and MMP-3 increased 3-fold (p <0.001) within the renal cortex 24 h following nephrectomy, and then gradually decreased to the control level after 7 days. In contrast, expression of MMP-2 and MMP-9 remained unchanged following nephrectomy. TIMP-1 mRNA levels also significantly increased 4-fold (p < 0.001) within the renal cortex 12 h following nephrectomy, followed by a decreaseto the control level after 3 days. In contrast, the glomerular expression of MMP-1, -2, -3 and TIMP-1 remained stable while minimal MMP-9 mRNA was detectable. MMPs and TIMP-1 may be associated with the early stages of renal hypertrophy following unilateral nephrectomy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 13:59:12