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Titolo:
Analysis and metaanalysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders
Autore:
Furlong, RA; Rubinsztein, JS; Ho, L; Walsh, C; Coleman, TA; Muir, WJ; Paykel, ES; Blackwood, DHR; Rubinsztein, DC;
Indirizzi:
Univndambridge, Addenbrookes Hosp, Dept Med Genet, Cambridge CB2 2QQ, Engla Univ Cambridge Cambridge England CB2 2QQ Genet, Cambridge CB2 2QQ, Engla Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP hol, Cambridge CB2 1QP, England UnivdCambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, Englan Univ Cambridge Cambridge England CB2 2QQ hiat, Cambridge CB2 2QQ, Englan Univdlothian,h, Royal Edinburgh Hosp, Dept Psychiat, Edinburgh EH10 5HF, Mi Univ Edinburgh Edinburgh Midlothian Scotland EH10 5HF nburgh EH10 5HF, Mi
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 1, volume: 88, anno: 1999,
pagine: 88 - 94
SICI:
0148-7299(19990205)88:1<88:AAMOTP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANIC-DEPRESSIVE ILLNESS; NO ASSOCIATION; SAMPLE; TH; CHROMOSOME-11; MARKERS; LINKAGE; LOCUS; DRD2;
Keywords:
tyrosine hydroxylase gene; stratified analysis; bipolar affective disorder; unipolar affective disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Rubinsztein, DC Univdgembridge, Addenbrookes Hosp, Dept Med Genet, Box 158,Hills Rd, Cambri Univ Cambridge Box 158,Hills Rd Cambridge England CB2 2QQ
Citazione:
R.A. Furlong et al., "Analysis and metaanalysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders", AM J MED G, 88(1), 1999, pp. 88-94

Abstract

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and noradrenaline. While positive associations between TH and bipolar affective disorder have been found in several studies, many studies have failed to reproduce these results. In order to clarify this situation, association studies of bipolar and unipolar affective disorder groups and metaanalyses of published data on the TH tetranucleotide repeat polymorphism were done. The association studies used the TH tetranucleotide repeat polymorphism in intron 1 and a PstI polymorphism at the 3' end of the gene. The study comprised 124 unrelated bipolar patients, 126 unipolar patients, and 242 controls. There was no significant association of either bipolar or unipolar affective disorder with the TH tetranucleotide repeat polymorphism. However, a weak association (chi(2) = 3.946, 1 df, P = 0.047; odds ratio, allele 2 vs. allele 1 = 0.71 (95% CI, 0.51-0.996)) was observed in the unipolar sample with the TH-PstI polymorphism. Three metaanalyses of published data on the TH tetranucleotide repeat polymorphism in major affective disorderwere performed: bipolar I + II vs. control using 583 cases and 745 controls; unipolar vs. control using 204 cases and 359 controls; and bipolar + unipolar vs. control using 846 cases and 823 controls. In each analysis there was no association of the TH tetranucleotide repeat polymorphism and affective disorder. These results do not support the tyrosine hydroxylase gene having a major role in the etiology of bipolar affective disorder. However, our data suggest that this locus should be examined in larger samples of unipolar affective disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88: 88-94, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 06/04/20 alle ore 07:56:42