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Titolo:
Kallmann syndrome gene (KAL-X) is not mutated in schizophrenia
Autore:
ONeill, M; Brewer, W; Thornley, C; Copolov, D; Warne, G; Sinclair, A; Forrest, S; Williamson, R;
Indirizzi:
Univstraliarne, Royal Childrens Hosp, Dept Paediat, Parkville, Vic 3052, Au Univ Melbourne Parkville Vic Australia 3052 diat, Parkville, Vic 3052, Au Univ Melbourne, Royal Childrens Hosp, Ctr Hormone Res, Parkville, Vic 3052, Univ Melbourne Parkville Vic Australia 3052 one Res, Parkville, Vic 3052, Mental Hlth Res Inst, Melbourne, Vic, Australia Mental Hlth Res Inst Melbourne Vic Australia , Melbourne, Vic, Australia Royal Pk Hosp, Melbourne, Vic, Australia Royal Pk Hosp Melbourne Vic Australia Pk Hosp, Melbourne, Vic, Australia Royalalialdrens Hosp, Murdoch Inst Res Birth Defects, Melbourne, Vic, Austr Royal Childrens Hosp Melbourne Vic Australia ects, Melbourne, Vic, Austr
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 1, volume: 88, anno: 1999,
pagine: 34 - 37
SICI:
0148-7299(19990205)88:1<34:KSG(IN>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; SMELL IDENTIFICATION TEST; CHROMOSOME; LINKAGE; LOCUS; HETEROGENEITY;
Keywords:
schizophrenia; Kallmann syndrome; anosmia; hypogonadotropic hypogonadism; KSV model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Sinclair, A Univstraliarne, Royal Childrens Hosp, Dept Paediat, Parkville,Vic 3052, Au Univ Melbourne Parkville Vic Australia 3052 lle, Vic 3052, Au
Citazione:
M. O'Neill et al., "Kallmann syndrome gene (KAL-X) is not mutated in schizophrenia", AM J MED G, 88(1), 1999, pp. 34-37

Abstract

Kallmann syndrome and schizophrenia share several clinical features, including dysfunctional olfactory ability, hypogonadotrophic hypogonadism, an excess of affected males, and psychiatric presentation. Because of this congruence, it has been proposed that up to 70% of male schizophrenics might have mutations affecting the function or expression of the gene mutated in Kallmann syndrome, KAL-X, We identified and studied 9 unrelated males with schizophrenia (as defined by DSM-IIIR criteria) who also have severe anosmia (first percentile of normal range) and low sex drive (seventh percentile of the normal range), and we sequenced the exons and the intron-exon junctionsof the KAL-X gene for each. We found no mutations, and conclude that schizophrenia is rarely, if ever, due to a mutation in the coding sequence or splice junctions of KAL-X. Am, J, Med. Genet. (Neuropsychiatr, Genet.) 88:34-37, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:01:17