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Titolo:
Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees
Autore:
Kendler, KS; MacLean, CJ; Ma, YL; ONeill, FA; Walsh, D; Straub, RE;
Indirizzi:
Virginia23298onwealth Univ, Med Coll Virginia, Dept Psychiat, Richmond, VAVirginia Commonwealth Univ Richmond VA USA 23298 t Psychiat, Richmond, VA VirginiaVAommonwealth Univ, Med Coll Virginia, Dept Human Genet, Richmond,Virginia Commonwealth Univ Richmond VA USA 23298 t Human Genet, Richmond, Queens Univ, Dept Psychiat, Belfast, Antrim, North Ireland Queens Univ Belfast Antrim North Ireland Belfast, Antrim, North Ireland Hlth Res Board, Dublin, Ireland Hlth Res Board Dublin IrelandHlth Res Board, Dublin, Ireland
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 1, volume: 88, anno: 1999,
pagine: 29 - 33
SICI:
0148-7299(19990205)88:1<29:MLDOC5>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
VULNERABILITY LOCUS; MICROSATELLITE LOCI; DEMOGRAPHIC HISTORY; FAMILIES; MUTATION; POPULATIONS; REGION; PATTERNS;
Keywords:
linkage disequilibrium; association; Ireland; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kendler, KS Virginiaichmond,ealth Univ, Med Coll Virginia, Dept Psychiat, Box 980126, R Virginia Commonwealth Univ Box 980126 Richmond VA USA 23298 R
Citazione:
K.S. Kendler et al., "Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees", AM J MED G, 88(1), 1999, pp. 29-33

Abstract

Linkage disequilibrium (LD) is a potentially powerful tool for the localization of disease genes for complex disorders. Most prior studies of the relationship between genetic distance and LD have examined only very short distances, focusing on the role of LD in fine-mapping and positional cloning. We examine here the relationship between marker-to-marker (M-M) LD and somewhat greater genetic distances. We analyzed 622 RI-M pairings on chromosomes 6p, 8p, and 5q in 265 native Irish pedigrees ascertained for a high density of schizophrenia, LD, significant at the 5% level, was found for 96% of all M-M pairings within 0.5 cM, for 67% within 0.5-1 cM, for 35% within 1-2cM, for 15% within 2-4 cM, for 8% within 5-10 cM, and for 7% above 10 cM, Thus, in Irish families selected for a high density of schizophrenia, M-M LD may be very common within 0.5 cM and frequent up to distances of 2 cM. AmJ. Med. Genet. (Neuropsychiatr. Genet.) 88:29-33, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 07/08/20 alle ore 00:13:53