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Titolo:
Increased production of hyaluronan by peritoneal cells and its significance in patients on CAPD
Autore:
Lai, KN; Szeto, CC; Lai, KB; Lam, CWK; Chan, DTM; Leung, JCK;
Indirizzi:
Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong Univ Hong Kong Hong Kong Hong Kong Hosp, Dept Med, Hong Kong, Hong Kong Prince Wales Hosp, Dept Chem Pathol, Shatin, Hong Kong Prince Wales Hosp Shatin Hong Kong Dept Chem Pathol, Shatin, Hong Kong
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 2, volume: 33, anno: 1999,
pagine: 318 - 324
SICI:
0272-6386(199902)33:2<318:IPOHBP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIALYSIS PATIENTS; EQUILIBRATION TEST; CONNECTIVE-TISSUE; ACID METABOLISM; MACROPHAGES; SERUM; INTERLEUKIN-1-BETA; MORPHOLOGY; ACTIVATION;
Keywords:
CAPD; mesothelial cells; macrophages; hyaluronan; peritoneal transport; peritonitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Lai, KN Univulamg Kong, Queen Mary Hosp, Dept Med, Room 411,Professorial Block,Pokf Univ Hong Kong Room 411,Professorial Block,Pokfulam Rd Hong KongHong Kong
Citazione:
K.N. Lai et al., "Increased production of hyaluronan by peritoneal cells and its significance in patients on CAPD", AM J KIDNEY, 33(2), 1999, pp. 318-324

Abstract

Hyaluronan (HA) is a polysaccharide that forms a critical component of extracellular matrices. HA is present in high concentrations in tissues undergoing remodeling and morphogenesis, and it appears to have an important rolein the early stages of wound healing. Here, we studied the level of HA in the peritoneal dialysate effluent (PDE) from 116 stable continuous ambulatory peritoneal dialysis (CAPD) patients. Longitudinal studies over a period of 6 weeks were performed in seven of these patients who developed peritonitis, The median HA level in PDE from these patients was 154.6 mu g/L (range, 29.7 to 820.2 mu g/L). Dialysate level of HA increased with age of the patients, but no such correlation was shown between HA level in PDE and duration of CAPD treatment or previous episodes of peritonitis. Patients with high or average peritoneal membrane transport of small solutes had a higher HA level in the PDE than those with a low peritoneal membrane transport (P =0.046). A significant correlation was observed between PDE level of HA andinterleukin-1 beta (IL-1 beta) or IL-6. The plasma level of HA in these patients was significantly greater than that of healthy controls (P < 0.0001), yet the plasma concentration of HA was only 85% that of the PDE concentration, In CAPD patients with peritonitis, there was a sharp increase in the PDE levels of HA, IL-l P, and IL-6. These values decreased progressively with resolution of peritonitis. The changes in the PDE levels of HA closely followed those of IL-1 beta or IL-6, In vitro [H-3]-glucosamine incorporation studies suggest that the main bulk of HA is derived from synthesis by theperitoneal mesothelial cells, whereas the amount synthesized by macrophages is trivial, We conclude that elevated levels of HA found in the PDE of stable CAPD patients originate from increased synthesis by peritoneal mesothelial cells. This event may serve as a marker of regeneration and remodelingof the peritoneal lining. (C) 1999 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 09:02:07