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Titolo:
Comparative analgesic efficacy of nimesulide and diclofenac gels after topical application on the skin
Autore:
Sengupta, S; Velpandian, T; Sapra, P; Mathur, P; Gupta, SK;
Indirizzi:
All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 l, New Delhi 110029, India
Titolo Testata:
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
fascicolo: 4-5, volume: 11, anno: 1998,
pagine: 273 - 278
SICI:
1422-2868(199807/10)11:4-5<273:CAEONA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORMALIN TEST; PAIN; PHARMACOKINETICS; MICE;
Keywords:
nimesulide; diclofenac; topical gel; antinociception; tail flick latency; writhing test; formalin test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Gupta, SK All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 hi 110029, India
Citazione:
S. Sengupta et al., "Comparative analgesic efficacy of nimesulide and diclofenac gels after topical application on the skin", SKIN PH APP, 11(4-5), 1998, pp. 273-278

Abstract

Nimesulide is a newer non-steroidal anti-inflammatory drug (NSAID) with selective cyclo-oxygenase (COX)-2 blocking property and has demonstrated a potent analgesic and antiinflammatory activity on oral and rectal administration. However, the C-max through both these routes is reached only after 3 hof administration. Dose-dependent gastrointestinal side effects also limitthe concentration of drug that can be achieved at the site of inflammationwhen administered through these routes, The present study was conducted toevaluate the antinociception induced by a new gel formulation of nimesulide when applied on the skin. Efficacy of topical nimesulide gel 1% (w/w) wasstudied on mice in the acetic-acid-induced writhing, tail flick latency (TFL) test and formalin-induced pain models, The antinociceptive effect of nimesulide was compared to diclofenac gel (1% w/w), Both the drugs induced dose-dependent analgesia with peak effect seen between 90 and 120 min after treatment, Greater antinociceptive effect (expressed as percent maximum possible effect) was seen in the writhing test than in the TFL test, indicatingthe peripheral action of both drugs, Nimesulide evidenced significant protection in the first phase of formalin-induced pain indicating modulation ofperipheral nociceptors unlike other conventional NSAIDs, This suggests that COX-2 may be a primary contributor to afferent evoked increase in prostanoid-mediated changes in pain processing, Antinociception seen following drug application on the skin was lower than that seen on intraperitoneal administration, indicating localised action following topical application, The findings of the present study suggest that the transgel formulation of nimesulide provides significant analgesic activity when applied topically.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:33:01