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Titolo:
Improved imaging of liver metastases with stimulated acoustic emission in the late phase of enhancement with the US contrast agent SH U 508A: Early experience
Autore:
Blomley, MJK; Albrecht, T; Cosgrove, DO; Patel, N; Jayaram, V; Butler-Barnes, J; Eckersley, RJ; Bauer, A; Schlief, R;
Indirizzi:
Hammersmith Hosp, Dept Imaging, London W12 0HS, England Hammersmith Hosp London England W12 0HS Imaging, London W12 0HS, England Schering, Dev Diagnost, Berlin, Germany Schering Berlin GermanySchering, Dev Diagnost, Berlin, Germany
Titolo Testata:
RADIOLOGY
fascicolo: 2, volume: 210, anno: 1999,
pagine: 409 - 416
SICI:
0033-8419(199902)210:2<409:IIOLMW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROBUBBLES;
Keywords:
liver neoplasms, metastases; liver neoplasms, US; ultrasound (US), contrast media; ultrasound (US), Doppler studies; ultrasound (US), technology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Blomley, MJK Hammersmith Hosp, Dept Imaging, Du Cane Rd, London W12 0HS, England Hammersmith Hosp Du Cane Rd London England W12 0HS , England
Citazione:
M.J.K. Blomley et al., "Improved imaging of liver metastases with stimulated acoustic emission in the late phase of enhancement with the US contrast agent SH U 508A: Early experience", RADIOLOGY, 210(2), 1999, pp. 409-416

Abstract

PURPOSE: To see whether stimulated acoustic emission (SAE) in the liver parenchyma in the late phase of enhancement with SH U 508A increases the conspicuity of occult metastases at ultrasonography (US). MATERIALS AND METHODS: Eighteen patients with known hypo- or hypervascularhepatic metastases underwent US after SH U 508A administration, after a delay of at least 5 minutes, to ensure decay of blood pool enhancement. In 16patients with visible metastases, conspicuity was compared on registered SAE and gray-scale scans by two blinded readers and by using computerized analysis of relative gray-scale and color Doppler conspicuity scores inside and outside the lesion. In nine patients, areas suspected of being involved but without definite gray-scale masses were imaged in the same way. Paired sections were analyzed by two blinded readers looking for parenchymal colordeflects without corresponding gray-scale masses; nine control images fromthree healthy volunteers were also included. RESULTS: Intense, transient parenchymal SAE was seen in all subjects. All metastases appeared as areas of reduced or absent signal. The conspicuity score was 80% for SAE versus 9% for gray-scale US (P < .001,Wilcoxon signed rank test). SAE-specific II defects were seen in all patients but in none of the volunteers. Metastases seen on SAE but undetectable on gray-scale images were proved in three patients. CONCLUSION: SAE with SH U 508A improves the conspicuity of metastases. SAE-specific defects may reveal isoechoic or subtle metastases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 12:24:25